Purpose: Hangeshashinto (TJ-14), a Kampo medicine comprising seven types of herbs, has been used in Japan to alleviate the side effects associated with anticancer drug treatments. However, the pharmacological effects of this medicine currently remain unclear. The present study aimed to demonstrate the efficacy of TJ-14 against anticancer drug-induced stomatitis, the pain associated with which may have a negative impact on mastication and swallowing. Methods: Mucositis was induced in Sprague-Dawley rats by cancer chemotherapy. Changes in body weight, stomatitis grades, histopathological scores, and oral bacterial counts were examined among TJ-14-treated, saline-treated, and Control (no treatment) rats. In vitro studies, including cell proliferation and wound healing assays, using epidermal keratinocyte and fibroblast cell lines were conducted. Results: The local application of TJ-14 exerted strong antibacterial effects and attenuated oral chemotherapy-induced stomatitis in rats. TJ-14 also increased the viability and invasion of epidermal keratinocytes and fibroblasts. Conclusion: The present results demonstrated the potential of TJ-14 to attenuate chemotherapy-induced stomatitis.
No effective, reliable treatment for stomatitis associated with cancer therapy has been established. This study focused on the its effectiveness of ozone nano-bubble water (ONBW) for the treatment of chemotherapy-induced stomatitis. Oral mucositis was induced in 14-week-old male Sprague-Dawley rats (N = 21). The animals were randomly divided into 3 groups: 7 without treatment (control); 7 treated with physiological salt solution (saline); and 7 treated with ONBW. Animals were weighed on Days 7, 9, 11, and 16. Stomatitis grade evaluation and bacterial count measurements were performed before rinsing in all animals 3, 5, and 10 days after acetic acid irritation (Days 9, 11, and 17 respectively). Weight loss after stomatitis creation was observed in all groups, with significant differences between the control and ONBW groups and between the saline and ONBW groups on Day 16. The stomatitis grade did not worsen during the experimental period in any group, with the lowest grades in the ONBW group on Days 11 and 16. Significant differences were identified between the control and ONBW groups and between the saline and ONBW groups on Days 11 and 16. Oral bacterial counts tended to decrease over time in all three groups, with the greatest decrease in the ONBW group, followed by the saline group. The decrease in the bacterial count was steepest in the ONBW group. Rinsing out the oral cavity with ONBW decreased bacterial counts and encouraged the healing of oral chemotherapy-induced stomatitis. ONBW may be an effective treatment for chemotherapy-induced stomatitis.
Abstract:Crohn's disease is a chronic granulomatous inflammatory disorder that is often accompanied by oral symptoms. We herein report a case of Crohn's disease that initially occurred as gingival swelling. A 63-year-old woman complained of gingival swelling and was referred to our clinic. During the disease course, Behcet's disease was denied despite the development aphthous ulcers and erythema nodosum. Thereafter, abdominal pain, diarrhea and weight loss were observed, and Crohn's disease was subsequently diagnosed by endoscopy. Because oral symptoms may precede Crohn's disease, it is important to include this possibility in the differential diagnosis when encountering patients presenting with oral swelling and ulcerative lesions.
Abstract:Pilocarpine hydrochloride (Salagen Ⓡ ) is a therapeutic drug used to treat xerostomia caused by Sjögren' s syndrome (SS) , whose effectiveness has been confirmed. However, some patients treated with this agent develop polyhidrosis, nausea, and increased micturition. These side effects can reduce compliance with regimens containing this medicine. In this retrospective study, we examined the effects of an herbal medicine (Byakkokaninjinto Ⓡ ) on the development of polyhidrosis in SS patients treated with Salagen Ⓡ for xerostomia. Sixteen SS subjects were given 15mg of pilocarpine per day for the first four weeks, after which we initiated treatment with a combination of herbal medicines (Byakkokaninjinto Ⓡ ) in eight cases and in others were given 15mg of pilocarpine hydrochloride alone per day. Consequently all cases involve a polyhidrosis symptoms ; this regimen was continued for twelve weeks. A reduction in polyhidrosis symptoms was observed in six patients (75.0%) . These results suggest that polyhidrosis caused by pilocarpine hydrochloride can be reduced with treatment with herbal medicine (Byakkokaninjinto Ⓡ ) . In this study, the promotion of salivation induced by pilocarpine hydrochloride was maintained.
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