LIPOSOMAL ENCAPSULATED ALPHA-LIPOIC ACID, BENFOTIAMINE AND CURCUMIN PREVENT OVERFEEDING MEDIATED INCREASES IN WAIST CIRCUMFERENCE INTRODUCTION: To determine if liposomal (L) encapsulated alpha-lipoic acid (0.5g), benfotiamine (0.5g) and curcumin (2.0g) (ABC) would prevent the unfavorable metabolic consequences of sedentary high-fat overfeeding in healthy young adults. METHODS: 29 young (18-30 years), healthy, physically active men and women were randomly assigned to ingest placebo (n=9), ABC (n=10), or L-ABC (n=10) twice daily for 28 days. Between days 22 and 28 all participants abstained from their normal regular exercise and consumed a high calorie, high fat diet. RESULTS: On Day 29, circulating alpha lipoic acid was greater (p<0.01) in L-ABC (412±73 ng/mL) compared with ABC (154±33 ng/mL). During the sedentary high fat overfeeding, dietary intake was not different (p>0.6) between groups (~3,400 kcal/day; ~50% from fat). Sedentary high fat overfeeding increased (p<0.05) waist circumference in the placebo (+2.7±2.7 cm) and ABC (+3.3±2.0) groups but not the L-ABC group (+0.7±2.7). The magnitudes of increase (p<0.05) in body mass (1.7±0.3 kg), fat mass (0.7±0.2 kg), and blood pressure (3±1 mmHg) and decrease (p<0.05) in insulin sensitivity (Matsuda Index:-2.9±0.9) after overfeeding were not different between groups (all p>0.50). DISCUSSION: Liposomal encapsulated alpha-lipoic acid, benfotiamine and curcumin: 1) promoted alpha-lipoic acid bioavailability; and, 2) prevented sedentary high-fat overfeeding mediated increases in waist circumference in usually active healthy young adults. These data iii may have important public health implications for periods of inactive overconsumption such as during seasonal celebrations.
Oxidative stress is adversely associated with heart rate variability and may be favorably modified with ingestion of antioxidants. The purpose of this study was to determine if prior ingestion of liposome encapsulated vitamin C favorably modifies the cardiac autonomic response to a high‐calorie meal. Ten young healthy adults (age: 26 ± 2 years, body mass index: 24.0 ± 1.4 kg/m2; blood pressure: 113/68 ± 3/2 mmHg; mean ± SE) ingested either a placebo or 5 g of liposome encapsulated vitamin C. Two hours later, they ingested a high‐calorie liquid meal (979 kcal; 30% fat, 64% carbohydrate, 6% protein). Circulating vitamin C concentrations, blood pressure and heart rate variability were measured over 6‐hours. Compared with placebo (0.7 ± 0.1 mg/dL), liposome encapsulated vitamin C ingestion appreciably increased circulating vitamin C (peak: 3.3 ± 0.1 mg/dL; P<0.01); concentrations remained high at 6‐hours (2.0 ± 0.1 mg/dL). Systolic blood pressure was increased following the meal however the magnitude of increase was lower with prior liposome encapsulated vitamin C (time × treatment interaction: P=0.019). Heart rate variability (standard deviation of R‐to‐R interval) was greater in the placebo compared with liposome encapsulated vitamin C (main effect: 104 ± 3 vs. 94 ± 3 ms; P=0.04) and decreased 1‐hour after the meal (main effect: 102 ± 5 vs. 87±5 ms; P=0.02); liposome encapsulated vitamin C did not influence this response (P=0.563). Similarly, the LF/HF ratio was greater with liposome encapsulated vitamin C compared with placebo (main effect: 7.3 ± 1.4 vs. 12.0 ± 1.4; P=0.041). Liposome encapsulated vitamin C appreciably increased circulating vitamin C concentration, favorably modified the systolic blood pressure response to a high‐calorie meal while potentially unfavorably modifying the heart rate variability response.Support or Funding InformationEmpirical LabsThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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