Hypercoagulability occurs in 15% of patients with malignancy and represents a clinical spectrum ranging from abnormal coagulation tests but no clinically evident thromboembolic disease, to arterial and venous thrombosis, migratory thrombophlebitis, nonbacterial thrombotic endocarditis (NBTE) and disseminated intravascular coagulation. The combination of increased procoagulant activity and decreased fibrinolytic activity accelerates the prothrombotic potential of endothelial cells in malignancy. NBTE is a rare manifestation of cancer-induced hypercoagulability and is commonly seen with mucin-producing adenocarcinomas, but rarely seen with ovarian clear cell carcinoma (OCCC). Cerebrovascular embolization ranges from 14–91% in NBTE. We report a rare case of a 62-year-old female presenting with occipital stroke as a consequence of NBTE in OCCC. Association of NBTE in OCCC has only been reported in 2 cases so far, but presentation with stroke has never been reported in the literature.
RESUMO O caso apresentado é uma paciente, vítima de atropelamento, a qual apresentou hipertensão intracraniana causada por uma trombose do seio transverso. É sabido que a trombose venosa cerebral, ou seja, a trombose de veias e seios venosos cerebrais é uma condição rara, geralmente subdiagnosticada. Uma de suas consequências é o aumento da pressão intracraniana (PIC), devido a uma deficiência de drenagem venosa cerebral e aumento do compartimento vascular. Após a administração de heparina de baixo peso molecular houve controle da hipertensão intracraniana.
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