Background: Pfeiffer syndrome (PS) is an autosomal dominant disorder caused by mutations in fibroblast growth factor receptor FGFR1 and FGFR2 genes, occurring in approximately 1:100,000 live births. PS has a wide range of clinical expression and severity, so early prenatal diagnosis is difficult and genetic counseling is desirable. We describe a PS newborn with her ultrasound and molecular studies. Case Report: We describe a female term newborn with cloverleaf-shaped skull, facial hypoplasia, low ears, exophthalmos and wide, broad and deviated thumbs and hallux. The patient was diagnosed by ultrasound at 29 WGA and referred to a tertiary care hospital for her follow-up. Molecular test revealed a heterozygous pathogenic variant in intron 8 of the FGFR2 gene (FGFR2: c.940-1G>C). It was a de-novo mutation. At 17 days of life, craniosynostosis correction and a Lefort-III frontomaxillary advancement were performed. Conclusion: Pfeiffer syndrome is a devastating genetic disorder. Prenatal diagnosis according PS morphological features in prenatal ultrasound allows timely genetic counseling, early referral to third-level centers, and close follow-up in the prenatal and postnatal stages.
Objective: Conduct a literature review to provide an estimate of changes in weight and body composition among university students and evaluate whether these changes are exclusive to the first year of academic life. Methods: Searches were performed in the PubMed/MEDLINE, Scopus, Web of Science, ScienceDirect, LILACS and SciELO databases for relevant articles published between 2007 and 2018. Only longitudinal studies involving concomitant evaluations of changes in weight and body composition were included. Two independent researchers performed the selection of the articles. Results: Eleven articles met the eligibility criteria and were included in the review. The tendency toward an increase in weight and body fat during academic life was confirmed, especially in the first year. Gains in weight and body fat in the freshman year of university were reported in all studies and ranged from 1.0 to 2.1 kg and 0.7 to 1.3%, respectively. Among the majority of students, the gain in body weight was the result of an increase in body fat. Conclusion: University students experience gains in weight and body fat during their academic lives, especially in the first year of university.
Native tropical forests hold high levels of diversity, challenging forest restoration of large areas in a global change scenario. For a site-specific restoration is required the understanding of the main influences ruling the assemblages. We aimed to answer three questions. 1) how do environmental variables influence taxonomic, phylogenetic diversities, and the phylogenetic structure in the of Rio Doce Basin (TFRD)? 2) How do environmental variables, phylogenetic structure and the main types of seed dispersal relate to each other? 3) Which information of the TFRD assemblages can be used for ecological restoration and conservation? We used 78 sites with their checklists to calculate taxonomic, and phylogenetic diversities, phylogenetic structures, and dispersal proportions. Then, we related the diversities of the sites to their bioclimatic variables and built GLM models. Species richness was influenced negatively by water excess duration, by water deficit duration, and positively by maximum temperature, and temperature seasonality. Water regime drives diversity and phylogenetic community structure in the TFRD more than other variables. Annual precipitation and maximum temperature presented the clearer influences on diversity and phylogenetic structure. Zoochory was positively, and anemochory, autochory were negatively related to sesMPD. By choosing the lineages with high fitness for each site, the functioning and the stability of ecosystems should increase. The addition of species with anemochory and autochory increases functional and phylogenetic diversity in areas with extreme water excess or water deficit, important in a global change scenario. A high proportion of zoochory allows the communities to function conserving dispersers, biodiversity, and services.Implications for practiceThe use of objective methods based on community assembly rules enhances the choice of species, and of phylogenetic lineages better fitted to the bioclimatic profiles of the areas to be restored, improving the functioning and stability of the restored forests.The water purification service should be improved through forest restoration as much as possible because ecosystem services and biodiversity conservation are co-benefits of restored forests.The inclusion of species with anemochory, and autochory in forest restoration practices should become usual, as they increase functional, and phylogenetic diversities, and as a consequence, the ecosystem stability.A large proportion of species with zoochory in restored forests co-benefits taxonomic diversity, phylogenetic diversity, and ecosystem stability.
This study aimed to describe an outbreak of abomasal bloat in kid goats and its clinical, pathological, microbiological, molecular, and epidemiological characteristics. In the kidding season, increased mortality of kid goats with a history of abdominal bloating, dullness, and death was reported. Clinical examinations were carried out, and biological samples from necropsied kids (n = 11) were collected for pathological, microbiological, and molecular diagnosis. Likewise, an epidemiological survey was carried out in order to verify possible associated factors related to the disorder. A therapeutic protocol was also implemented. The main necropsy findings were dehydration, pale mucosa, ascites, abomasal and intestinal meteorism and congestion, emphysematous abomasitis, and cranial areas of lung consolidation. Through staining techniques for cytological evaluations of the abomasum, it was possible to identify Gram positive bacteria, coccoid, with a cuboid shape suggestive of Clostridium ventriculi, Gram positive bacilli suggestive of Clostridium perfringens and ovoid basophilic yeasts compatible with Saccharomyces cerevisiae. By anaerobic culture and molecular tests, C. ventriculi and C. perfringens type A were confirmed. The main histopathological findings were cholangiohepatitis, nephrosis, emphysematous abomasitis, hyalinization of the gastric and intestinal walls, gastroenteritis, intestinal thromboembolism, pulmonary edema, and non-purulent pneumonia, overall suggesting a systemic enterotoxemia picture. The early detection of sick kids and quick initiation of treatment were the primary determinants of the prognosis of each case. There was a final mortality rate of 24.4% (20/82), and the agents C. perfringens type A and C. ventriculi were identified as the main ones involved, with the possible participation of S. cerevisiae. Among the possible associated factors, the erroneous use of the milk replacer associated with inadequate kid management was verified. Among the prophylactic measures, hygiene care, proper use of milk replacer, vaccination plan containing C. perfringens alpha toxoid associated with a good colostrum management were suggested. Outbreak of abomasal bloat in goat kids due to Clostridium ventriculi and Clostridium perfringens type A in Brazil Outbreak of abomasal bloat in goat kids
Resumo: Nosso objetivo neste trabalho foi analisar o comportamento dos bancos pú-blicos, no que tange à sua lógica de oferta de empréstimos no interregno 1995-2010, analisando, mais especificamente, o comportamento do Banco do Nordeste. A compreensão é de que a decisão da oferta de empréstimos dos bancos públicos envolve uma decisão entre aplicações alternativas e isso ocorre mesmo considerando que esses bancos teriam uma lógica particular, definida pela implantação de políticas específicas. A nossa hipótese é que entre 2000 e 2007, o comportamento dos bancos públicos se dirigiu a uma lógica de maior semelhança com a lógica da atuação dos bancos privados. Paralelamente, após 2008, seria possível verificar uma mudança de performance, com um importante avanço das operações de créditos, quando esses bancos atuam de forma anticíclica. No entanto, a nossa hipótese é a de que esse avanço privilegiou os tomadores "mais seguros", contribuindo para uma maior concentração do perfil dos emprésti-mos. Os dados desenvolvidos comprovaram essa hipótese. Palavras-chave:Sistema Financeiro Nacional, Bancos Públicos, Banco do Nordeste. Classificação JEL: E51Portfolio dynamics of public banks in the period 1995/2010 and an analysis of the release of BNB resources Abstract: Our goal in this study was to analyze the behavior of public banks in terms of their loans supply logic in the interregnum 1995-2010, analyzing more specifically the Bank of Northeast 's behavior. The understanding is that the public banks lending bid decision involves a choice between alternative applications and this occurs even considering that these banks have a particular logic, defined by the implementation of specific policies. Our hypothesis is that between 2000 and 2007 the behavior of the public banks turned to a logic of similarity to the logic of the performance of private banks. At the same time, after 2008 it would be possible to see a change
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