As part of a continuing search for new potential anticancer candidates, we describe the synthesis, cytotoxicity and mechanistic evaluation of a series of 4-oxoquinoline-3-carboxamide derivatives as novel anticancer agents. The inhibitory activity of compounds 10-18 was determined against three cancer cell lines using the MTT colorimetric assay. The screening revealed that derivatives 16b and 17b exhibited significant cytotoxic activity against the gastric cancer cell line but was not active against a normal cell line, in contrast to doxorubicin, a standard chemotherapeutic drug in clinical use. Interestingly, no hemolytical activity was observed when the toxicity of 16b and 17b was tested against blood cells. The in silico and in vitro mechanistic evaluation indicated
OPEN ACCESSMolecules 2014, 19 6652 the potential of 16b as a lead for the development of novel anticancer agents against gastric cancer cells.
This article presents information about the physico-chemical properties of hydrazine, as well as its toxicity, industrial synthesis and its application in industry and organic synthesis. Keywords: Hydrazine; industrial synthesis; nucleophile; industrial applications. Resumo: Este artigo contém informações sobre as propriedades físico-químicas da hidrazina, bem como sua toxicidade, síntese industrial e aplicações na indústria e na síntese orgânica. palavras-chave: Hidrazina; síntese industrial; nucleófilo; aplicações industriais.
This article presents a review of different methods of industrial synthesis of hydrochloric acid, such as: direct synthesis; chlorination of organic compounds; Mannheim process and Hargreaves reactions. Data on physico-chemical properties, toxicity and the main applications of hydrochloric acid are also presented.
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