Background: Sirtuin 1 (SIRT1) has been associated with longevity and protection against cardiometabolic diseases, but little is known about how it influences human vascular function. Therefore, this study evaluated the effects of SIRT1 activation by resveratrol and energy restriction on vascular reactivity in adults. Methods: A randomized trial allocated 48 healthy adults (24 women and 24 men), aged 55 to 65 years, to resveratrol supplementation or energy restriction for 30 days. Blood lipids, glucose, insulin, C-reactive protein, noradrenaline, SIRT1 (circulating and gene expression), and flow-mediated vasodilation (FMD) and nitrate-mediated vasodilation (NMD) were measured. Results: Both interventions increased circulating SIRT1 (p < 0.001). Pre- and post-tests changes of plasma noradrenaline were significant for both groups (resveratrol: p = 0.037; energy restriction: p = 0.008). Baseline circulating SIRT1 was inversely correlated with noradrenaline (r = −0.508; p < 0.01), and post-treatment circulating SIRT1 was correlated with NMD (r = 0.433; p < 0.01). Circulating SIRT1 was a predictor of FMD in men (p = 0.045), but not in women. SIRT1 was an independent predictor of NMD (p = 0.026) only in the energy restriction group. Conclusions: Energy restriction and resveratrol increased circulating SIRT1 and reduced sympathetic activity similarly in healthy adults. SIRT1 was independently associated with NMD only in the energy restriction group.
A hipertensão arterial (HA) é uma condição clínica caracterizada por elevação sustentada dos níveis pressóricos maior ou igual a 140 e/ou 90 mmHg. As diretrizes atuais têm apontado cada vez mais estudos que verificam a influência dos diferentes padrões alimentares e seus efeitos benéficos no controle da HA, como: Dietary Approach to Stop Hypertension (DASH) que preconiza o consumo de frutas, hortaliças, fibras, minerais e laticínios com baixos teores de gordura; DASH-Sodium a qual combina três níveis diferentes de ingestão de sódio; Dieta Mediterrânea (MedDiet) caracterizada pela ingestão reduzida de carne vermelha e processada, ovos, doces e bebidas açucaradas, somada ao consumo moderado de peixes, vinho tinto e laticínios com baixo teor de gordura e alta ingestão de azeite de oliva; Plant based cujo escopo é consumir principalmente proteínas de origem vegetal, com um padrão alimentar rico em fibras, que inclua cereais integrais, frutas, legumes, leguminosas e nozes, com uma ingestão regular de peixes e frutos do mar, laticínios com baixo teor de gordura. Todas essas intervenções mostraram benefícios nos níveis pressóricos, porém a DASH é o padrão alimentar mais frequentemente recomendado e com maior nível de evidência para a prevenção primária e o controle da HA.
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