BackgroundArsenic exposure is an established cause of skin, lung and bladder cancer [1][2][3][4]. Several animal studies show that arsenic toxicity affects thyroid hormone metabolism. A single case report documents development of thyroid cancer in a patient of promyelocytic leukemia after oral arsenic trioxide therapy [5]. There is no study in the English scientific literature of the relationship between thyroid disease and arsenic exposure in human population.The Indian state of West Bengal is affected by arsenic contamination of ground water. According to The World Health Organisation (WHO), 2011 report 6 of the 23 districts of West Bengal are higher affected areas [6]. ObjectivesTo study the role of arsenic in development of thyroid disease. MethodsSeven patients with thyroid disease who attended the outpatient clinic of the Department of ENT Head and Neck Surgery of a tertiary teaching hospital were recruited for this study. After obtaining informed consent approximately 0.25 gm hair and nail samples were collected from each patient.
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