Before exposure, the experimental group (Fig. 1a) showed 25% accuracy (s.d. 11%), which is not significantly different from 33% chance (binomial from chance: Pǃ0.9). Exposure for 21 days doubled the androstenone-detection accuracy in both the exposed nostril (from 25% to 55%, change from baseline: t(11)ǃ3.3, P<0.007; binomial from chance: P<0.002) and the unexposed nostril (from 25% to 49%, change from baseline: t(11)ǃ2.3, P<0.04; binomial from chance: P<0.02). There was no significant difference in the extent of improvement between the exposed and unexposed nostrils (t(11)ǃ0.4, Pǃ0.7).We screened a further 50 subjects to obtain 12 more non-detectors (9 female) for a control study (Fig. 1b) in which we tested for confounding possibilities: first, subjects were initially selected for nondetection, and thus their performance could either remain the same or improve, but not deteriorate (a 'floor effect'); second, even a minute leak in the block may have enabled the blocked nostril to learn; third, participation in olfactory testing may improve performance over time. The control study was identical to the experimental, except that both nostrils were blocked.Control subjects (Fig. 1b) did not differ from the experimental group at baseline (mean accuracy at baseline: experimental group, 25%, s.d. 11; control group, 27%, s.d. 11, t(22)ǃ0.44, Pǃ0.7), and remained at chance detection after 21 days of exposure (change from baseline: t(11)ǃ1.6, Pǃ0.14; binomial from chance: Pǃ0.4). The difference between the two groups after exposure (mean accuracy after 21 days, average for both nostrils) was 52% (s.d. 20) in the experimental group and 35% in the control group (s.d. 14; t(22)ǃ2.3, P<0.03), negating possible confounding factors.We exploited the paired anatomy of the olfactory system 5,6 to demonstrate that the plasticity that underpins the emergence of androstenone detection originates in the central components of the olfactory system. These components may be likened to pattern recognition, which occurs at the olfactory bulbs or in primary olfactory cortex -a substrate that shares information from both nostrils 7 and is optimized for olfactory learning 8-10 . We do not rule out a contribution to plasticity from the peripheral components of the olfactory system 11,12 -peripheral receptors may be induced in the unexposed nostril in response to a central signal (direct or hormonal, for example). It remains to be determined how central and peripheral mechanisms could interact to maximize plasticity in the olfactory system.