BackgroundEpistaxis is a common reason patients present to the emergency department. There is significant variation in climate across Canada. Our study aimed to determine if epistaxis is related to season, temperature and humidity in a Maritime climate.MethodsEthics approval was obtained. A retrospective chart review was performed. Patients who presented to the Saint John Regional Hospital Emergency Room between July 2015 and December 2017 with a diagnosis of epistaxis were identified. Weather data was collected from Environment Canada. We performed multiple univariate analyses examining confounding variables.ResultsIn total, 476 cases of epistaxis were identified. There was a significant seasonal variation; the highest number of epistaxis cases occurred in the winter (p < 0.001). A negative correlation was seen between mean daily humidity and epistaxis (R2 = 0.7794).ConclusionThe highest number of cases presented in the winter and a negative correlation was found between epistaxis and mean daily humidity.

The Impella device was found to improve procedural and hemodynamic parameters, but only limited randomized data are available regarding clinical outcomes associated with its use. Large, multicenter RCTs are needed to definitively establish the effectiveness of the Impella device among high-risk PCI patients.

Background: Aspirin-exacerbated respiratory disease (AERD) represents an aggressive form of chronic rhinosinusitis with nasal polyposis that is notoriously challenging to treat. There is evidence to suggest desensitization to aspirin may improve symptomatology and disease control in these patients. The goal of our study was to critically appraise the literature on this topic and assess the effect of desensitization on sinonasal symptomatology. Methods:We searched EMBASE, CINAHL, MEDLINE, and the Cochrane Library for relevant literature. Studies were included if they were observational studies or randomized, controlled trials, had n > 1, and were published in English or French. Studies were excluded if they were systematic reviews. We assessed study for quality and presence of common sources of bias. Results:Twenty-four studies met the inclusion criteria. In general, polyp size, polyp recurrence, nasal symptom scores, sense of smell, number of acute rhinosinusitis episodes, and systemic steroid use improved when patients were desensitized. The vast majority of studies recommend desensitization. Conclusion:There is mounting evidence that aspirin desensitization is a valuable adjunct to treat sinonasal symptoms in the treatment of patients who have AERD. C 2020 ARS-AAOA, LLC.

Systematic review of drospirenone: best studies show no or slightly increased VTE risk (versus levonorgestrel).

We found an elevated risk of VTE associated with drospirenone-containing COCs in comparison with levonorgestrel-containing COCs in both cohorts. While left truncation of healthcare databases is a concern for the identification of first-time users, the use of a more explicit cohort of restarters suggests a doubling of VTE risk with drospirenone-containing COCs.

Little evidence was found of a greater incidence of arterial thrombosis with drospirenone versus levonorgestrel contraceptives.