Introduction: Burnout syndrome is a state of mental and physical exhaustion caused by excessive and prolonged stress. The aim of the research was to determine the influence of stress factors on the quality of life of workers in the surgical and internal medicine department. Methodology: The study was designed as a cross-sectional study with 150 subjects. The research was conducted at the University Hospital Foca, surgical and internal medicine department. We used a sociodemographic questionnaire, a questionnaire to assess the health status and the work related scale of stress. Statistical analysis was performed using the SPSS ver. 24.0. Results: The frequency of the burnout syndrome as a response to chronic stress is high (20%). The lower level of the quality of life of the respondents was found in dimension mental health (49.36%) and vitality (62.93%). Workers on the surgical ward are most obvious overloaded (82.60%) and have a lower quality of life. Disscussion and Conclusion: The most common stress-related factors of workers in the surgical department are overloaded with work, financial constraints, call time, a small number of health care workers.
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