Traditionally, before the beginning of the Christmas season in Lviv, the Department of Clinical Immunology and Allergology of Danylo Halytsky Lviv National Medical Uni- versity, headed by the Honorary Doctor of Ukraine, Doctor of Medical Science, Pro- fessor Valentyna Chopyak, organizes inter- national conferences on clinical immunolo- gy, allergology and related disciplines. This year, which is the tenth anniversary of this tradition, the Conference, held on December 9-10, was dedicated to the most urgent issue of the year “COVID-19, LONG-COVID-19, POST-COVID-19: THEIR MULTIPLICITY AND IMMUNE DISORDERS”. The conference was organized jointly with the Ministry of Health of Ukraine, NAS of Ukraine and NAMS of Ukraine, Danylo Halytsky Lviv National Medical University, Department of Health of Lviv Regional Administration, Lviv Regional Clinical Diagnostic Center, LLC “Lviv Medical Institute”, Ukrainian Society of Immu- nology, Allergology and Immunorehabilitation and the Shevchenko Scientific Society.
Herpes simplex virus has the ability to persist during all the life in the nervous ganglia and cells of the immune system with periodic reactivation and the development of a wide range of clinical manifestations. Clinical manifestations depend on the immune status of the host- from typical vesicular rashes on the red border of the lips, to the development of serious neurological complications, sometimes fatal (usually in immunocompromised people). Immunocompromised patients include patients with congenital immunodeficiencies, HIV infection, iatrogenic immunosuppression after transplantation, as well as patients with systemic connective tissue diseases who receive long-term immunosuppressive therapy. On the other hand, herpesviruses are triggers, under the influence of which there may be a failure of self-tolerance in genetically predisposed individuals. Thus, there is a kind of «vicious circle», when herpes becomes recurrent in people with the existing immunodeficiency, and then the virus itself maintains this condition by persistence and replication in the nerve ganglia and immunocytes. Aim. Assessment of lymphocyte status by lymphocyte phenotyping and determination of activation markers activity in patients with activated HSV 1/2 infection in combination with Connective Tissue Disease (CTD) and compare with groups of patients with CTD only, patients with only activated HSV 1/2 infection and practically healthy individuals. Materials and methods. We monitored 110 patients: 34 individuals with reactive herpes simplex virus infection, 40 individuals with systemic connective tissue disease, and 36 individuals with a combination of reactive herpes simplex virus infection and CTD. Conclusions. Defects in the humoral and cellular parts of the immune system in patients with CTD can provoke inadequate immune protection against pathogenic microorganisms, and lifelong persistence of HSV type 1/2 in immune system cells can lead to death or decreased functional activity of immune system cells and secondary immunodeficiency.
This article presents the results of the investigation of IFN-α synthesis dynamics on local and general levels in patients with the recurrent simple herpesvirus infection. The influence of different types of antiviral therapy to IFN-α level is estimated as well. The normalization of IFN-α level was noted in the group of patients with simple herpesvirus infection after applying of antiviral therapy and three months after the treatment, especially in the group of patients with mild course of HSV 1/2 infection, that proves the antiviral defence stabilization. Moreover, the clinical efficacy of the proposed treatment was established for patients with the recurrent HSV 1/2 infection: in the group of patients with the mild course of HSV 1/2 infection it was 73.5% after the treatment and 85.8% in the remote period; in the group of patients with the mild and severe course of HSV 1/2 infection it was 64.0% after the treatment and 70.4% in the remote period.
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