Modern socio-philosophical discourse is in a state of humanistic reorientation. Hence, the subject of scientific exploration is the theoretical and methodological substantiation of humanistic principles of the scientific picture of the world. The research aims to develop the constants of humanism, which constitute a humanistically oriented sociocultural space. The result of the work is the illumination of the interaction of fundamental humanistic aspects of responsibility, activity, creativity, and self-organization. Humanism differs significantly from its previous versions in its modern socio-philosophical interpretation. First of all, it deals with the realities of modern human civilization, balancing between dialectical confrontation and synergetic combination. This is how the methodological basis of the humanities-science discourse is formed, which increasingly gravitates toward a philosophical-synergetic manifestation. Philosophy and science of the present interpret the human being not only in the classical natural science or humanities perspective. The dichotomy of transdisciplinarity (which generates diversity) and anthropocentrism (which is grounded in the supremacy of the human being) is relevant today. Humanistic orientation acts as a regulator for the rapid development of scientific and technological progress, in which moral and spiritual values are lost. Thus, the humanistic paradigm forms the methodological guidelines for the social cluster.
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