This study aimed to develop a model that fused multiple features (multi-feature fusion model) for predicting metachronous distant metastasis (DM) in breast cancer (BC) based on clinicopathological characteristics and magnetic resonance imaging (MRI). A nomogram based on clinicopathological features (clinicopathological-feature model) and a nomogram based on the multi-feature fusion model were constructed based on BC patients with DM (n=67) and matched patients (n=134) without DM. DM was diagnosed on average (17.31±13.12) months after diagnosis. The clinicopathological-feature model included seven features: reproductive history, lymph node metastasis, estrogen receptor status, progesterone receptor status, CA153, CEA, and endocrine therapy. The multi-feature fusion model included the same features and an additional three MRI features (multiple masses, fat-saturated T2WI signal, and mass size). The multi-feature fusion model was relatively better at predicting DM. The sensitivity, specificity, diagnostic accuracy and AUC of the multi-feature fusion model were 0.746 (95% CI: 0.623-0.841), 0.806 (0.727-0.867), 0.786 (0.723-0.841), and 0.854 (0.798-0.911), respectively. Both internal and external validations suggested good generalizability of the multi-feature fusion model to the clinic. The incorporation of MRI factors significantly improved the specificity and sensitivity of the nomogram. The constructed multi-feature fusion nomogram may guide DM screening and the implementation of prophylactic treatment for BC.

Introduction: The sharp deterioration in the physical development of the younger generation is worrying. The morbidity of youth has increased by 29.9% compared with the last century. More than 33% of boys and girls, among first-year students with chronic diseases. The aim: Assessing the state of the students’ body by examining the results of a survey among the second- and third-year students of the university using a specially designed questionnaire. Materials and methods: The material on the assessment of the state of health and the characteristics of the organism has been processed by studying the results of a survey of young men and women aged 20-23, obtained on the basis of using the developed questionnaire. Results: Physical development has been studied in accordance with the state of health of the students, as well as a thorough study of a number of criteria: diseases of the musculoskeletal system were 37.1%, 49.7% and 43.45 among boys aged 20, 22 and 23 and respectively 33.3 %, 38.6% and 47.7% among girls in their 20s, 22s and 23s. The morbidity of eye was 18.0%, 3.8% and 9.9% among boys aged 20, 22 and 23 years and 17.7%, 17.1% and 7.7% among girls aged 20, 22 and 23 years. Conclusions: In the structure of morbidities are diseases of the musculoskeletal system, diseases of the nervous system and the organ of vision. Correlation of the characteristics of the level of students’ health and their physical development have indicators on the level of educational adaptation and the number of diseases.

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The publication provides a comprehensive analysis of the state and development of national education over the 30 years of Ukraine’s independence, identifies current problems in education, ascertains the causes of their emergence, offers scientifically reasoned ways to modernise domestic education in the context of globalisation, European integration, innovative development, and national self-identification. Designed for legislators, state officials, education institutions leaders, teaching and academic staff, the general public, all those who seek to increase the competitiveness of Ukrainian education in the context of civilisation changes.

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The study reveales psycholinguistic peculiarities of understanding of indirect meaning of the proverbs and idioms of Ukrainian speaking pre-school children. The experiment took place on the basis of pre-school education establishments of Ukraine. The participation number is 378 children at the age of 5 years (till 5.5 years). The used psycholinguistic methods are: а) «evaluation of understanding of the indirect metaphors meaning» (Vygotskyi, 2000); b) «evaluation of proverbs understanding» (Luriia, 1998). The other used psycholinguistic methods are: а) «Proverbs understanding» (Luriia, 1998), adopted for the diagnoses of metaphoric understanding of idioms meaning by children; b) «The interpretation choice of one of the given variants of meanings» (Baskakova & Glukhov, 2008; Eliseeva, Gutsc & Marini, 2017); c) selection of one of several possible paraphrases (Winner, Rosenstiel & Gardner, 1976; Vosniadou & Ortony, 1983). Children were proposed to express themselves in order to find out how they understand given proverbs and idioms. If they had difficulties in meaning explication, so they were proposed some variants of proverbs and idioms interpretations, among which the first was correct (with indirect meaning) and the second with the direct meaning and the third with occasional associative meaning. The experiment proved such results: there are children with obvious intuitive language ability to feel the general meaning of proverbs and idioms. The part of children of the age of five years is able to verbalize the indirect proverb meaning (4,2%) and idioms meaning (7,4%). In the situation with one variant of meaning among some paraphrases 16,4% of children chose the correct proverb meaning, 20,4% of children chose the correct idiom meaning. More difficult for children’s understanding are proverbs, than idioms. It could be explained in the way, that idiomatic expressions are one whole and one nomination that a child often interprets in daily life from adults in some specific life situations. That is why he or she uses more quickly the heard word complex in a new association chain, abstracting from the direct meaning of idiomatic words. The proverb understanding is seen by child as more complex cognitive task, which foresees decipherment of the common thought or conclusion, understanding its meaning (implication). That is why the proverbs cause more problems among children than idioms.

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