From the early days until now, textbook knowledge and research about the renin-angiotensin system (RAS) have focused on the renal, vascular and central effects of the main effector hormone of the system, angiotensin II (Ang II). It is still widely unknown that all the RAS components are also expressed in skin, which is why working on the cutaneous RAS is sometimes like being caught between two stools: the scientific RAS community regards the skin as irrelevant as a target organ for the RAS and the dermatology/skin research community regards the RAS as irrelevant for skin physiology and pathophysiology. Despite this hindrance, the number of publications on the cutaneous RAS has steadily risen since the first description of the expression of all components of the RAS in rodent and human skin and is now in the hundreds. [1,2] These studies have provided strong evidence that the RAS is in fact
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