Title of Study: Effects of aspirin dose escalation on platelet function and urinary thromboxane and prostacyclin levels in normal dogs Pages in Study: 75Candidate for Degree of Master of Science Eight dogs were enrolled in a randomized, cross-over study that used optical aggregometry and a platelet function analyzer to evaluate platelet function before and after the administration of 5 aspirin dosages: 0.5 mg/kg q24h, 1 mg/kg q24h, 2 mg/kg q24h, 4 mg/kg q24h and 10 mg/kg q12h. Urine 11-dehydro-thromboxane-B2 (11-dTXB2) and 6-keto-prostaglandin-F1alpha (6-keto-PGF1alpha), were measured. Compared to pretreatment, there were significant decreases in maximum aggregometry amplitude and increases in PFA-100 closure times for all doses except 0.5 mg/kg q24h. There was no difference in amplitude or closure time between the 2 mg/kg, 4 mg/kg, and 10 mg/kg q12h dosages. At 2 mg/kg q24h, 100 percent (aggregometry) of dogs were aspirin responders. There was a significant decrease in urinary 11-dTXB2-and 6-keto-PGF1alpha-to-creatinine ratios with aspirin administration. An aspirin dosage of 2 mg/kg q24h consistently inhibits platelet function in healthy dogs without decreasing prostacyclin synthesis significantly more than lower aspirin dosages.ii DEDICATION I would like to dedicate this research to my parents,
A 13-year-old female spayed boxer presented for severe hypoglycaemia. Electrolyte concentrations were within reference range, and adrenocorticotropic hormone (ACTH) stimulation test results were consistent with hypoadrenocorticism. Abdominal ultrasound revealed pancreatic and hepatic nodules. The left adrenal gland was of normal size, but the cranial pole of the right adrenal gland was enlarged. While the patient was severely hypoglycaemic, the insulin concentration was above reference range, consistent with insulinoma. The patient was hospitalised on dextrose supplementation and discharged on prednisone and directions to feed small, frequent meals. Surgery to remove the insulinoma was declined by the owner. When the hypoglycaemia became refractory to increasing doses of prednisone, diazoxide was added. Two months following initial presentation, the patient was euthanased due to refractory hypoglycaemia. Postmortem examination revealed a pancreatic islet cell carcinoma with metastatic lesions in the liver and pancreatic lymph nodes, a pituitary carcinoma that stained strongly positive with ACTH antibody, and adrenocortical necrosis.
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