The results of experimental studies of parasitic contamination degree using bioindicators T.canis for monitoring areas of technologically transformed territories are given. The reliability of using the methods of bioindication of ecological and parasitological state of technologically transformed territories (for example, m. Kyiv) is confirmed. The results were obtained by using exponent of domination of toxocara invasive stages in selected soil samples with a help of flotation methods with ammonium nitrate.
Autoimmune diseases are chronic progressive processes associated with dysfunction of the central and peripheral structures of the nervous system. The understanding of the processes taking place inside the body has changed significantly thanks to modern technologies, which made it possible to identify the close relationship of the intestine with the nervous, endocrine, and immune systems of a person. It is believed that the majority of chronic diseases of multifactorial nature are based on changes in the species diversity of the gut microbiota, which leads to irreversible damage to the homeostasis of the microorganism. Dysfunction associated with changes in the composition, diversity and metabolic activity of the gut microbiota leads to the development of inflammation and some chronic diseases. Many scientific authors conducted data analysis of the role of the gut microbiota in the development of autoimmune diseases and the possible ways of correction. A number of issues concerning the interaction of macro- and microorganisms are being actively studied and require further clarification. Changes in the immune status of the human body, which occur during the restructuring of the gut microbiome in patients with autoimmune diseases, are important. Compensation of nutritional imbalance, gut microbiota, as well as physical activity adequate for age and living conditions, allows providing energy homeostasis and is a promising direction for preventing the development and reducing the rate of progression of autoimmune diseases. Key words: gut microbiota, autoimmune diseases, immune dysfunction, homeostasis, probiotics, lifestyle modification
Objective: to assess the influence of clinical indicators on the nature of the prognosis for different types of multiple sclerosis (MS) using correlation analysis Correlation analysis was carried out between clinical indicators characterizing different time stages (premorbid stage, debut, remission after debut and recurrent stage in recurrent and secondary-progressive (SP), progression stage in SP and primary progressive course of MS. In graphical form, structures were obtained that selectively unite groups of indicators with high connections (0.95 and higher) in the so-called clinical and statistical syndromes, which in the form of a special network were a system of connections between clinical symptoms (indicators) during the entire period of the disease development. In the obtained correlation structures, two levels of organization of connections were distinguished: intra-stage and inter-stage, which have different structural organization for different types of MS flow. For each type of course, three groups of indicators are identified: the first group (the so-called “centers of influence”) includes indicators from which the arrows are directed to other symptoms; the second group (the so-called “controlled” indicators), which “accumulate” incoming influences from the outside; the third group (the so-called “transit” indicators), which simultaneously have both influence networks and controlled networks, i. e. equally combine two alternative options. Analysis of the connections between the indicated groups of indicators with different informational value determined the further nature of the forecast. The study made it possible to prove that the formation of a prognosis within the framework of a single nosological form (MS) occurs as a result of a complex multilevel structural reorganization of correlations between individual clinical indicators, both at different time stages and with different types of the course of the disease.
Introduction: Type 2 diabetes is a chronic health condition affecting hundreds of millions of people. Type 2 diabetes has traditionally been combated with a combination of lifestyle modification, insulin therapy and pharmacological agents, including sulfonylureas, biguanides, thiazolidinediones and alpha-glucosidase inhibitors. Type 2 diabetes is associated with an increased risk of cardiovascular disease and the development of diabetic kidney disease. Although sulfonylureas are low-cost drugs and widely prescribed, they have been shown in recent cardiovascular outcome trials to present a high risk of hypoglycemia, which in turn increases the risk of negative cardiovascular outcomes. Metformin, a biguanide that is the most commonly-prescribed antidiabetic agent worldwide, is contraindicated in patients with risk factors for lactic acidosis, including heart failure and chronic kidney disease. Objectives: The last decade has seen significant advances in the development of novel antidiabetic agents shown to possess both reno- and cardioprotective qualities. This article aims to review the available literature and recent studies demonstrating the efficacy and safety of these agents individually, as well as exploring areas of future development in the field. Method: The reporting of this review is based on the 2020 PRISMA statement. A literature search for all papers related to antidiabetic medication was conducted using reliable sources such PubMed and Google Scholar Databases, including a recent meta-analysis of renal and cardiovascular outcome trials. Conclusion: A critical analysis of clinical trials on type 2 diabetes and the two most severe comorbidities in cardiovascular and chronic kidney diseases may help cardiologists, urologists and diabetes specialists to adapt their therapeutic approaches to individual patients. Data related to antidiabetic effects of agents of natural origin accompanied by their Cardioprotective and renoprotective capacity testify benefits of these compounds as novel therapeutic agents.
Уперше розглянуто питання біоіндикаційного картографування еколого-паразитологічного стану техно-генно трансформованих територій. Описано та апробовано методику створення картосхем місцевості щодо паразитарного забруднення на території міста Києва.
Abstract. Preliminary few studies indicate that age, gender and duration of acne vulgaris (acne) affect the quality of life of these patients.Objective - to assess the impact of the duration and severity of acne on quality of life of patients in gender, age and professional aspects in connection with the treatment.Material and methods: 98 patients with acne aged 18-29 years, among whom 36 were males (36,73 %), and 62 (63,26 %) females have been examined. The assessment of acne severity classification was carried out according to the classification of the American Academy of Dermatology, while the quality of their life was assessed by means of SF- 36 questionnaire.Results. Mild acne was found in 6 (6,12 %) patients, moderate one in 72 (73,47 %), severe one in 20 (20,41 %) cases. It was established that clinically significant severity of acne was more common in younger male patients (22 years). However, a greater impact on quality of life was found in female patients, older than 22 years, with professions associated with being among a large group of people and in case of long course (more than 4-5 years) of dermatosis. Mild acne had little impact on quality of life.Standard complex acne treatment during two months significantly improved quality of life indicators of patients with moderate degree of acne and most of the indicators in those with severe disease, which, however, didn’t reach the indicators in the people of the control group, and it shows the necessity to improve the programme of treating and preventive measures concerning such patients.Conclusion: Patients with acne have significant changes in life quality, depending on their gender, age and professional peculiarities as well as on the severity of dermatosis course. Determining the indicators of life quality by means of SF-36 questionnaire is an important aspect of the patient’s physical and psychiatric health assessment as well as a reliable criterion of their treatment efficacy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.