Objective To determine the frequency of Human leukocyte antigen alleles and to verify the association of the presence of these alleles with symptoms and other diseases related to celiac disease in patients with autoimmune thyroid diseases. Methods A questionnaire on the symptoms and diseases associated with celiac disease was applied. Genomic deoxyribonucleic acid was extracted by collecting cells from the oral mucosa. The alleles (DQA1*0501; DQB1*0201; DRB1*04) were identified by means of the polymerase chain reaction. Results A total of 110 patients with autoimmune thyroid diseases participated in this study. It was observed that 66.4% of the individuals carried at least one of the alleles assessed and that 58.2% of the individuals were positive for at least one of the DQ2 alleles (DQA1*0501; DQB1*0201) and out of these 18.2% were positive for both DQ2 alleles (DQA1*0501; DQB1*0201). With regard to DQ8 (DRB1*04), 21.8% of the studied population was positive for this allele and 3.6% was positive for both DQ2 (DQA1*0501; DQB1*0201) and DQ8 (DRB1*04). A significant association was found between the presence of the DRB1*04 allele and gastrointestinal symptoms (p=0.02). A significant association of the DRB1*04 allele with type 1 diabetes mellitus (p=0.02) was observed. Conclusion The genetic profiles most commonly associated with celiac disease, such as DQ2 (DQA1*0501; DQB1*0201) and DQ8 (DRB1*04) were around 20.0% prevalent in the studied population. These are risk haplotypes for celiac disease especially when symptoms and diseases related to celiac disease are present. Therefore, it is important to screen patients to investigate a potential diagnosis for celiac disease.
O presente relatório visa a descrever as ações desenvolvidas pelo projeto de extensão “Assistência nutricional ambulatorial a crianças” desenvolvido pela Faculdade de Nutrição junto ao ambulatório de Pediatria da Faculdade de Medicina (FAMED) da Universidade Federal de Pelotas (UFPel). O projeto tem como objetivo principal realizar atendimento nutricional a crianças e gestantes encaminhados pelos serviços de Pediatria e Ginecologia da FAMED e de unidades básicas de saúde da cidade de Pelotas e região. O atendimento é realizado semanalmente, mediante agendamento. Além de atendimentos individualizados, realizam-se ações de atendimento em grupo na perspectiva da educação alimentar e nutricional e saúde bucal. No ano de 2016, 65% das crianças foram encaminhadas com diagnóstico de sobrepeso ou obesidade, 6% desnutrição, 13% autismo - transtorno do déficit de atenção com hiperatividade ou neuropatias - 8% erros alimentar, entre outros. Na supervisão nutricional pré-natal, 46% das mulheres apresentavam obesidade anterior à gestação e foram encaminhadas para manejo do ganho de peso. Nas ações em saúde bucal, 56% das crianças atendidas foram encaminhadas para atendimento em consultório devido à cárie dentária. As ações desse projeto preenchem uma lacuna importante na assistência ambulatorial de crianças e gestantes de alto risco na comunidade de Pelotas e região.
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