In the testicles, the expression of Angiotensin-Converting Enzyme 2 receptors makes it more susceptible to infection by Sars-CoV-2 and, therefore, to male infertility with significant health problems for the patient. Therefore, this study aimed to analyze the clinical pathophysiology and the mechanisms involved in the genesis of male infertility from COVID-19, through the critical analysis of the main scientific evidence on the subject presented so far. From an integrative review of the literature containing 30 studies selected using inclusion criteria in the period 2020-2021, the direct and indirect impacts on male fertility in pathophysiological and psychosocial terms were observed in this study, in addition to therapeutic options, guidelines host and efficient semiological approach. Thus, the impact of the pandemic, even after one year, is immeasurable. Additional studies to reveal the real consequences and the mechanism by which the disease can affect male fertility are still needed. It is essential to pay more attention to male genital exams in patients with COVID-19. The psychobiological consequences of the pandemic in infertile patients should not be underestimated.

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The thoracic outlet syndrome results in the neurovascular structures compression in the designated region of the space between the collarbone and the first rib (thoracic outlet). May be divided between classic neurogenic or true, atypical neurogenic or vascular, and each one of them has a different compression mechanism and can be represented by a bony anomalous structure, costoclavicular reduction space or by the arm's hyper abduction. The diagnosis is complex, and complementary exams such as: radiography, MRI, angiography helps in the viewing of the involved structure. The treatment may be done in two ways: conservative (exercises for posture correction and muscular strengthening, combined with symptomatic treatment) and surgical, (the base is a resection of the first rib and may be associated with scalenectomy or cervical rib resection). The surgical technique by videothoracoscopic video-assisted surgery is poorly reported, therefore, technically attractive and related to less invasiveness and greater safety. In this article, it will be revised the facts about the pathology and its therapeutic approach.

Hypertensive patients with COVID-19 are susceptible to complications of the disease, so this study aimed to analyze the action of drugs that act on Angiotensin (TA) in the presence of COVID-19 in comparison with other antihypertensives, as well as to identify the main ones. evidence on the subject presented so far. It is an integrative literature review containing 34 articles selected according to the inclusion criteria, between January / 2020 to February / 2021, in the PubMed, Embase, Scopus and Web of Science databases. The results do not show a causal relationship between the increase in COVID-19 infection and the use of RAAS inhibitors, but a possible protective effect of these against the severe manifestation of the disease due to the inhibition of the pro-inflammatory diseases of AT II. Thus, about ⅔ of the studies defended the continuity of use and the protection factor of RAAS blockers to the detriment of the other classes of antihypertensive drugs that do not modulate RAAS. It was found, then, that antihypertensive treatment should be maintained, as it does not worsen the prognosis in the face of Sars-CoV-2 infection. However, the studies are mainly observational and, therefore, cannot establish strong causal relationships. For this reason, robust randomized controlled trials are needed to better understand this topic.