Aims: Consumption of glucose or foodstuff s with high glycaemic index (GI) in persons with type 1 diabetes mellitus (PWD1) is a hot topic in present diabetology. The aim of our pilot prospective study was to assess the effi ciency of empirically suggested simple algorithms for premeal boluses in PWD1 using insulin pumps and continuous glucose monitoring (CGM).Methods: Six PWD1 (aged 46.2±15.09 y, diabetes duration 14.5±9.65 y, HbA1c/IFCC 6.3±1.59%, BMI 23.6±1.67 kg/m 2 , mean±SD) on insulin pumps Paradigm 522/722 with RT-CGMS sensors (Medtronic MiniMed, Northridge, CA) underwent a 12-week CGM. In one week, subjects consumed 50g of carbohydrates in eleven alternative meals (rice squares, dark chocolate, white bread, honey, glucose, ravioli with meat and Eidam cheese, mashed potatoes with fi sh fi ngers, apricot dumplings with butter, spa waffl es, spalta squares, and tomato soup with pasta) eaten for breakfasts, lunches, snacks and dinners in order to calculate their GI. The insulin boluses were adjusted according to empirically defi ned algorithms. Average glucose levels and daily insulin doses over three one-week periods (before testing, testing and after testing) were compared.Results: During the observational period, the weekly averages of glucose levels (9.1±2.33 mmol/l vs. 9.2±2.30 mmol/l vs. 9.0±2.43 mmol/l, respectively) and daily insulin doses (39.1± 8.14 IU/d vs. 39.7±10.7 IU/d vs. 38.6±9.97 IU/d, respectively) were similar. One-week consumption of high GI foodstuff s had only a negligeable eff ect on average glucose levels. Conclusion:The suggested algorithms for premeal insulin boluses appear to limit the risk of potential hyperglycaemia resulting from intake of high GI foodstuff s.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.