Background
Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO definition), at 6- and 12-months follow-up, amongst previously hospitalised adults and children and assessed risk factors.
Methods
Prospective cohort study of children and adults with confirmed COVID-19 in Moscow, hospitalised between April and August, 2020. Two follow-up telephone interviews, using the International Severe Acute Respiratory and Emerging Infection Consortium survey, were performed at 6 and 12 months after discharge.
Results
One thousand thirteen of 2509 (40%) of adults and 360 of 849 (42%) of children discharged participated in both the 6- and 12-month follow-ups. PCC prevalence was 50% (95% CI 47–53) in adults and 20% (95% CI 16–24) in children at 6 months, with decline to 34% (95% CI 31–37) and 11% (95% CI 8–14), respectively, at 12 months. In adults, female sex was associated with PCC at 6- and 12-month follow-up (OR 2.04, 95% CI 1.57 to 2.65) and (OR 2.04, 1.54 to 2.69), respectively. Pre-existing hypertension (OR 1.42, 1.04 to 1.94) was associated with post-COVID-19 condition at 12 months. In children, neurological comorbidities were associated with PCC both at 6 months (OR 4.38, 1.36 to 15.67) and 12 months (OR 8.96, 2.55 to 34.82) while allergic respiratory diseases were associated at 12 months (OR 2.66, 1.04 to 6.47).
Conclusions
Although prevalence of PCC declined one year after discharge, one in three adults and one in ten children experienced ongoing sequelae. In adults, females and persons with pre-existing hypertension, and in children, persons with neurological comorbidities or allergic respiratory diseases are at higher risk of PCC.
Cold-formed steel studs and purlins with staggered slotted perforations in webs are used in building structures to produce a better thermal performance of the profiles and for the energy efficiency of structures. On the other hand, the slotted webs result in an unfavourable effect in terms of the structural performance of the element, prominently their shear, bending and combined bending and shear strengths. Relatively little research has been reported on this subject despite its importance. Many research studies have been undertaken to examine the behaviour of conventional cold-formed steel (CFS) channel sections subject to combined bending and shear. To date, however, no research has been carried out to investigate how CFS channels with staggered slotted perforations behave under combined bending and shear actions. An extensive study on this area is therefore essential. Finite element (FE) models of CFS channels with staggered slotted perforations were developed to investigate their combined bending and shear capacity. A parametric study was conducted in detail by developing FE models based on the validation process with available experimental data. This paper presents the FE analysis details of CFS channels with staggered slotted perforations subject to combined 2 bending and shear actions and the FE results. New design equations were also proposed to predict the combined bending and shear capacity of steel channels with staggered slotted perforations.
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