Introduction Preeclampsia is a pregnancy-specific syndrome. One of the hypotheses concerning the etiology of preeclampsia is vitamin D deficiency during pregnancy. Method and Materials The present study is a randomized controlled clinical trial which aims to determine the effect of vitamin D supplement on reducing the probability of recurrent preeclampsia. 72 patients were placed in control group while 70 patients were randomized to the intervention group. The intervention group received a 50000 IU pearl vitamin D3 once every two weeks. The control group was administered placebo. Vitamin D or placebo was given until the 36th week of pregnancy. Results The patients in intervention group have significantly lower (P value = 0.036) probability of preeclampsia than patients in the control group. The risk of preeclampsia for the control group was 1.94 times higher than that for the intervention group (95% CI 1.02, 3.71). Conclusion The intended intervention (i.e., prescription of vitamin D) has a protective effect against recurrent preeclampsia. Vitamin D supplementation therapy in pregnancy could help in reducing the incidence of gestational hypertension/preeclampsia. Registration This study has been registered in Iranian Registry of Clinical Trials (IRCT) site with ID number IRCT2017010131695N1.

This study assesses the effects of ginger on nausea and vomiting caused by pregnancy and compares it with metoclopramide medicine. This study was a randomized double-blind controlled trial. Metoclopramide, Ginger and placebo were putted in similar capsules. The medicines were administered three times a day. Then the Rhodes questionnaire was completed and its score were calculated. Data were analyzed by Chi square test, ANOVA and Repeated measurement. The intensity of changes in nausea, vomiting and Rhodes during study were statistically different in two groups of ginger and metoclopramide compared with placebo (p < 0.05), but it was not statistically significant between two groups of ginger and metoclopramide. According to our study, ginger is less effective than metoclopramide in reducing nausea and vomiting but it could be a good alternative for metoclopramide.

Objective: Having a rapid and low cost diagnostic approach in assessment of fetal wellbeing is an important goal for prenatal care process. The aim of this study was to determine the diagnostic value of rapid biophysical profile (rBPP) in comparison to biophysical profile (BPP). Materials and methods: In this study 142 pregnant women with insulin-dependent diabetes referred to Besat Hospital (Sanandaj, Iran) were evaluated in terms of fetal health. Age, gestational age and non-stress test (NST) data of patients were collected. The fetuses were evaluated using the standard BPP and selected rBPP methods. Sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) were calculated. The receiver operating characteristic (ROC) curve was plotted. The data were analyzed in Stata 14 software, using appropriate statistical analyses. Results: The mean ± standard deviation (SD) of maternal age and gestational age of the studied subjects were 30.6 ± 6.3 and 35.6 ± 1.5 weeks, respectively. The frequency of normal cases were 126 (88.7%) in the BPP method and 121 (85.2%) in the rBPP method. The results showed that sensitivity, specificity, PPV and NPV of rBPP in this study were 56.2%, 90.5%, 42.8% and 94.2%, respectively. The area under the ROC curve was 73.3%. Pearson Test showed a significant correlation between scores obtained through BPP and rBPP methods (p < 0.001). Conclusion: Considering the high profile of the sensitivity and PPV of the RBPP method compared to BPP, rBPP method has a better capacity to discriminate non-distressed fetuses from distress-exposed fetuses. It can also be used as a quick and easy method in crowded centers with limited evaluation tests, where not much skill is needed.

Background and Aim: Pregnancy is associated with many physiological changes that can affect the effectiveness of drugs. Our purpose in this study was to asses the pattern of drug use during pregnancy, self-administration consumption, maternal and fetal complications. Materials and Methods: This study was conducted on 1300 pregnant women referred to health centers of Sanandaj and south of Tehran during 2016-17. The information was obtained by interviewing mothers and examining the documentation of the delivery. Finally all data analysis was performed by SPSS software, v.18 and Chi square and T-test. Results:The largest age group of participants was 18-35 years old (80.2%). The most of them were housewives )78.5%) and 87.3% of them had at least a diploma. self-administration consumption was significantly more common in mothers with unwanted pregnancies and those who received their prenatal care from unskilled persons (P<0.05). Conclusion:In women with self-administration consumption, the mean of education was less. It is concluded that education system has a important role in the change of knowledge, attitude and performance. self-administration consumption more happened between they who were advised by unskilled assistance and they who had uwanted pregnancy. Therefore, we should extend Reproductive Health services for development of Iranian women and mothers society.

Purpose The purpose of this retrospective cohort study was to compare fertility rates of fresh versus frozen embryo transfer in antagonist IVF cycles. Methods This cohort study was performed on 105 patients referred to the infertility clinic of Besat Hospital in Sanandaj. These patients were admitted to this infertility clinic from March 2014 to March 2020. Inclusion criteria were infertile couples treated with antagonistic IVF cycle. In this study, we compared the fertility rate in antagonist IVF cycles in two patient groups, the group that fresh embryo was transferred, vs the group that received frozen-thawed embryo. Data collected during this study from both groups were analyzed and compared using SPSS statistical software. Results In this study, out of 105 patients included in the project, 48 were in the fresh embryo transfer group, and 57 were in the frozen embryo transfer group. The rate of chemical pregnancy was 12 (25%) in the fresh group and 15 (26.3%) in the frozen group (P: 0.878); The clinical pregnancy rate was 11 (22.9%) in the fresh group and 11 (19.3%) in the frozen group (P: 0.650); The rate of abortion in the fresh group was 3 (6.3%), and in the frozen group was 8 (14%) (P: 0.194); and live birth rate was 9 (18.8%) in fresh group, compared with 7 (12.3%) in the frozen group (P: 0.358). Conclusion The difference in rate of chemical pregnancy, clinical pregnancy, abortion, and live birth in antagonistic IVF cycles in the two groups of fresh embryo transfer versus frozen embryo transfer is not statistically significant. Although not statistically significant, the percentage of chemical pregnancy was higher in the frozen embryo transfer group. The percentage of abortion was also higher in the frozen embryo transfer group, and the percentage of clinical pregnancy and live birth were higher in fresh embryo transfer group.

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Background: Myo-inositol is an intracellular mediator which is involved in various aspects of reproduction in women. Objective: This study aimed to evaluate the impact of Myo-inositol on the outcomes of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles in infertile women. Materials and Methods: This double-blind randomized controlled trial was conducted on 70 infertile women referred to the Infertility Treatment Center, Besat hospital, Sanandaj, Iran from May 2019 to September 2019 for IVF/ICSI cycles. The participants were randomly divided into 2 intervention (n = 36) and control (n = 34) groups. The intervention group received 2000 mg of Myo-inositol and 200 mcg folic acid twice a day for 2 months and the control group received 200 mcg of folic acid twice a day for 2 months in the IVF/ICSI cycles (from the third day of cycle until the end of the second month). Finally, the number of oocytes, the quality of embryos, and the IVF/ICSI outcomes were compared between the 2 groups. Results: The mean numbers of oocytes, MII oocytes, and 2 pronuclear embryos were significantly higher in the intervention group than the control group. Also, the clinical pregnancy and live birth rates in the intervention group were significantly higher than in the controls (p = 0.04). Conclusion: The administration of Myo-inositol may increase clinical pregnancy and live birth rates by increasing the number of total and meiosis II oocytes in infertile women undergoing IVF/ICSI. Key words: Infertility, In vitro fertilization, Intracytoplasmic sperm injection, Myoinositol.