KEYWORDS ABSTRACTEnterobacteriacea, drug resistance, microbial, polymerase chain reaction, primer,DNA, Gene Scan to discover online

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The authors report a 12-year-old boy who was presented with headache, nausea, vomiting and seizure. His magnetic resonance imaging showed 2 adjacent tumors in the region of the left ventricular trigone. The pathology of tumors reported collision tumors composed of meningioma and malignant astrocytoma.

Xanthoma disseminatum (XD) is a rare benign mucocutaneous xanthomatosis that is classified as a benign non-Langerhans cell histiocytosis. We report a 62-year-old man who presented with widespread yellow-brown papulonodular and tumoral lesions on face, flexors, and trunk. Histopathological features of the cutaneous lesions were typical of XD.

Background:The purpose of this study was to determine the frequency of Serrated polyps of colonic polyps samples in Hazrat_e Rasoul_e Akram Hospital over ten years.Materials:The target group in this study was patients with colonic polyps in Hazrat_e Rasoul_e Akram Hospital. Pathologic evaluation of these patients was done. Serrated polyps, by location, gender, age and type of polyps were divided and frequency of them were determined separately.Results:Of 381 patients studied, 224 (58.79%) and 157(41.20%) were males and females, respectively. Mean age of patients was 59.25 years. In initial diagnosis, frequency of Adenomatous polyp, Hyperplastic polyp and Mixed polyp were 92.44% and 5.33%, and 2.22%, respectively. In final diagnosis (Second evaluation), frequency of Adenomatous polyp, Hyperplastic polyp, Mixed polyp, Sessile Serrated Adenoma/ Polyp, Traditional Serrated Adenoma and SPU (Serrated Polyp Unclassifiable) were 90.44%, 4.88%, 2.44%, 1.11%, 0.66% and 0.44%, respectively. 72.13% and 27.86% of polyps were low grade dysplasia and high grade dysplasia, respectively. According to the results of this study, the incidence of all types of polyps detected was more in men than women. Rectum and sigmoid were most abundant in the area polyp in both initial and final diagnosis.Conclusion:Despite the low prevalence of Serrated polyps in patients, early diagnosis is the best action to reduce morbidity and mortality. Probability of the risk of progression from low grade to high grade dysplasia and transforming into Adenocarcinoma is high in Serrated polyps.

A 12‐year‐old Iranian girl presented with a bathing trunk congenital melanocytic nevus. Multiple other pigmented lesions were present. The nevi were distributed over the entire body including the oral mucosa. There were also bilateral, soft, pendulous tumors and nodules in the area covered by the giant congenital melanocytic nevus. The tumors had been present since birth and showed continuous growth during childhood. She was otherwise healthy. Her parents were not consanguineous. There was no family history of similar lesions. Physical examination revealed a large dark‐brown circumferential plaque extending evenly from the upper back and abdomen down to the lumbar region, buttocks, and thighs (Fig. 1). It had a smooth surface, with excessive growth of hair. There were soft, redundant, exuberant folds of skin overhanging the back and buttock, localized to the area covered by the bathing trunk nevus. On palpation, they appeared as deep, multilobulated masses mimicking giant neurofibromas. There were also several smaller dark‐ or skin‐colored, soft, dermal nodules in this area. On other parts of the integument, there were numerous pigmented nevi of different sizes and colors, including speckled nevi, café‐au‐lait spots, and some clinically dysplastic nevi. There was hypertrichosis over some of the nevi. Mucosal examination revealed dark‐brown macules on the hard palate and conjunctiva. General physical examination was otherwise normal. There was no axillary freckling. Ophthalmologic examination was negative for Lisch nodules, and the fundal appearance was normal. Neurological examination revealed no abnormalities. Spinal X‐ray showed spina bifida occulta in the fifth lumbar vertebra. Brain and spinal magnetic resonance imaging (MRI) with gadolinium contrast was performed to detect neurocutaneous melanosis, which was negative. Two deep incisional biopsies were performed of the proliferative nodules over the hips, with the clinical impression of giant neurofibroma. Histologic examination revealed superficial nests of melanocytes with focal involvement of the dermo‐epidermal junction, extending into the dermis (Fig. 2). The melanocytes became spindle shaped within the reticular dermis (Fig. 3). Immunohistochemical techniques showed strong positive staining for both S100 protein and MART‐1 in both the superficial and deep portions of the proliferation, consistent with a melanocytic nevus. 1 Bathing trunk melanocytic nevus with large, pendulous skin lesions mimicking neurofibromas over the buttocks and lower back and multiple other melanocytic nevi of variable size distributed all over the body 2 Histologic examination of a pendulous pigmented mass reveals nests of melanocytes extending from the superficial into the deep dermis (low power, hematoxylin and eosin) 3 There is focal involvement of the dermo‐epidermal junction; melanocytes become spindle shaped within the reticular dermis (medium power, hematoxylin and eosin) As the pathological examination was consistent with proliferative nodules in a giant congeni...

BackgroundThe study was aimed at determining the prevalence of secondary amyloidosis in a group of Iranian patients with Rheumatoid Arthritis (RA), and the assessment of its correlation with the clinical and laboratory findings and data.MethodA total number of 220 patients (167 female and 53 male) with a minimum five-year history of RA were selected. Congo red staining method was used for staining the specimens obtained by abdominal subcutaneous fat biopsy (ASFB) method. All of the specimens were examined for apple-green birefringence under polarized light microscope. Clinical and laboratory characteristics of the patients were assessed. Chi-square test and unpaired student's t-test were run for intergroup comparisons.ResultsAmyloid deposition test yielded positive results in 15 out of the 220 cases (6.8%) examined by the ASFB technique. Thirteen patients were found to have minimal amyloid deposits. Of all the clinically significant cases, 8 (53%) presented with proteinuria, and 7 cases (46.6%) had severe constipation.ConclusionThe prevalence of fat amyloid deposits in Iranian patients with RA is low. In up to half of the study group the deposits were subclinical. Follow up studies are required to determine whether this subclinical amyloidosis can develop into full-blown clinically significant amyloidosis.

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