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The hydrothermal treatment of green carbon dots (CDs) is an appropriate fluorescent probe synthesis method. CDs are exploited as biological staining agents, especially for cellular detection and imaging. The nitrogen‐doped green carbon dots (N‐CDs) formation can improve the fluorescence intensity property in a one‐step process. Here, we report two N‐CDs from lemon and tomato extraction in the presence of hydroxylamine. Lemon and tomato N‐CDs showed the blue fluorescence under ultraviolet radiation of about 360 nm. The characterization of CDs and N‐CDs showed the presence of N‐H and C–N bonds which enhanced the fluorescence efficiency. The mean size of lemon and tomato N‐CDs were about 2 and 3 nm with an increased quantum yield (QY) of 5% and 3.38%, respectively. The CDs and N‐CDs cytotoxicity assay exhibited high cell viability approximately 85% and 73%, respectively. N‐CDs show superior fluorescent intensity in different solvents and significant stability under long‐time UV irradiation, different PH and high ionic strength. Our results indicated that the use of N‐CDs in cell imaging can lead to fluorescence intensity enhancement as well as proper biocompatibility. Therefore, the safe and high fluorescence intensity of green N‐CDs can be utilized for fluorescent probes in biolabeling and bioimaging applications.

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: The increasing prevalence of cancer has led to the expansion of traditional medicine objectives for developing novel drug delivery systems. A wide range of plant-derived polyphenol bioactive substances have been investigated in order to explore anti-cancer effects of these natural compounds and to promote effective treatment of cancer through apoptosis induction. In this regard, plant-derived polyphenol compounds including curcumin, silibinin, quercetin, and resveratrol have been the subject of intense interest for anti-cancer applications due to their ability in regulating apoptotic genes. However, some limitations of pure polyphenol compounds, such as poor bioavailability, short-term stability, low-cellular uptake, and insufficient solubility, have restricted their efficiency. Nanoscale formulations of bioactive agents have provided a novel platform to address these limitations. This paper reviews recent advances in nanoformulation approaches of polyphenolic drugs, and their effects on improving the delivery of chemotherapy agents to cancer cells.