The research studied physical and chemical water of Sobashi spring in Talafar to evaluate this water for different usages, due to the lack of permanent surface water and decreasing of ground water level as a result of dry seasons estimation of some heavy metals (Zn, Cu, Pb, Cd) for phragmites australis L., showed that: 1-The Sobashi spring water is very hard due to the high percentage of calcium and magnesium (2144-2682)(161-560) respectively, so its alkalinity where its pH is (8), analyses also revealed that this water is unsuitable for drinking according to (WHO) classifications, but it is possible to be used for agriculture. 2-Results of heavy elements in the water showed that the highest values for these elements were in Site 3 in January as reached (72, 22, 18, 0.9) elements (Zn, Cu, Pb, Cd) respectively as a result of sewage water in Sobashi spring water at this point. 3-Bioaccumulation of heavy metals of phragmites australis roots higher than Sorghum halepense L. and Imperata cylindrical plant roots. It is higher of then the rest of the plant tissues (stem, leaves, flowers). the order of contents of metal in these plants are as follows: Cd
The research included a determination of polyamine oxidase (PAO) activity in normal females and diabetic type I patients. It was found that the activities of PAO in red blood cells (RBC) and plasma in patients were significantly higher than that of normal (p<0.05). The partial purification of PAO from RBC of diabetic and normal females were included in this study. This was achieved by using different biochemical techniques. Three proteinous peaks with PAO activities in RBC (I, II, III) from each of normal, diabetic with specific activities (U\mg protein) (0.194,0.183 and 0.098), (0.349, 0.237 and 0.176) were isolated from ion exchange chromatography. Molecular weights (72588, 74512 and 69339), (141458, 100671 and 104018) Da respectively. This study didn't show the existence of Cu 2+ ion as a cofactor for any PAO isoenzyme, but indicated the existence of flavin adenine dinucleotide(FAD) as a cofactor for all PAO isoenzymes. On the other hand, the research included a preparation of thiourea derivatives of structure analogous to sulfonylurea drugs and containing thiosemicarbazide. Thiosemicarbazide showed an inhibitory effect on partially purified PAO activity. The prepared thiourea derivatives of thiosemicarbazide showed a competitive inhibition of PAO activity.
٢was studied by Glibenclamide and Rosiglitazone drugs, the best concentration of both inhibiters was 6mM. The mechanism of SDH inhibition by using both drugs were noncompetitive. There is no change in Km value 100 mM. Vmax value without inhibitor was 22.175 but 13.634 and 14.615 unit/ml with Glibenclamide and Rosiglitazone respectively. Accordingly, the inhibition constant Ki was calculated and appeared 7mM for both inhibitors above.Finally, we propose that action of these drugs may contribute to decrease patients with type I diabetes complications through inhibition SDH which plays an important role in polyol pathway.
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