Low back pain (LBP) is one of the most important health conditions that can affect human with physical and psychosocial changes. Nonspeci c LBP, de ned as self-limiting and which exact cause cannot be determined, is common among older adults. Besides, lumbar disc herniation should be the rst diagnosis that comes to mind in between 40-60 years-old patients with clinical ndings of radiculopathy with LBP.However, in order not to miss important causes such as malignancy that can cause LBP, the patient's anamnesis should be deepened, and physical examination should be performed carefully. We reported the case of a 53-year-old woman with anaplastic carcinoma of the pancreas (APC) where the initial symptom was LBP accompanied by radiculopathy and diagnosed by tru-cut biopsy from the sacral metastatic soft tissue mass, which was speci ed by the advanced imaging. APC is a rare cancer, and the survival time of the patients is quite short due to its rapid spread and resistance to chemotherapy and radiotherapy. Based on this case, clinicians should evaluate the patient detailly, prefer further imaging when necessary, and discuss the case with musculoskeletal radiologists when there are diagnostic problems, which will reduce the possibility of overlooking the underlying serious causes of LBP.
Low back pain (LBP) is one of the most important health conditions that can affect human with physical and psychosocial changes. Nonspecific LBP, defined as self-limiting and which exact cause cannot be determined, is common among older adults. Besides, lumbar disc herniation should be the first diagnosis that comes to mind in between 40–60 years-old patients with clinical findings of radiculopathy with LBP. However, in order not to miss important causes such as malignancy that can cause LBP, the patient's anamnesis should be deepened, and physical examination should be performed carefully. We reported the case of a 53-year-old woman with anaplastic carcinoma of the pancreas (APC) where the initial symptom was LBP accompanied by radiculopathy and diagnosed by tru-cut biopsy from the sacral metastatic soft tissue mass, which was specified by the advanced imaging. APC is a rare cancer, and the survival time of the patients is quite short due to its rapid spread and resistance to chemotherapy and radiotherapy. Based on this case, clinicians should evaluate the patient detailly, prefer further imaging when necessary, and discuss the case with musculoskeletal radiologists when there are diagnostic problems, which will reduce the possibility of overlooking the underlying serious causes of LBP.
The purpose of the study is to elucidate the interrelationships and notable correlations among the indicators of hormonal regulation, immune status, and markers of neurodegeneration in patients diagnosed with autoimmune thyroiditis. The study enrolled a total of 170 patients with autoimmune thyroiditis (divided subclinical and manifest form). Control group consist of 65 people without thyroid pathologies or other autoimmune diseases. The examination of cytokine profiles in patients with autoimmune thyroiditis revealed a significant increase in cytokine levels in groups of patients with subclinical and manifest forms of the disease compared to the control group. The analysis of antibody levels in patients with different clinical forms of hypothyroidism revealed that the median concentration of Ab-nDNA was significantly higher in patients with a manifest form of the disease compared to those with a subclinical group. According to an assessment of neuron-spesific enolase levels in the blood plasma of patients with autoimmune thyroiditis significantly compared to control group. Furthermore, a study examining the concentration of neuron-spesific enolase in patients with different clinical forms of autoimmune thyroiditis revealed that individuals with a subclinical form of the disease had statistically significant increase (p=0.042) in the value of this parameter. Our study results revealed significant changes in immunological parameters and markers of neurodegeneration in patients with autoimmune thyroiditis alongside hormonal imbalance.
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