SummaryBackgroundStudies evaluating titration of antihypertensive medication using self-monitoring give contradictory findings and the precise place of telemonitoring over self-monitoring alone is unclear. The TASMINH4 trial aimed to assess the efficacy of self-monitored blood pressure, with or without telemonitoring, for antihypertensive titration in primary care, compared with usual care.MethodsThis study was a parallel randomised controlled trial done in 142 general practices in the UK, and included hypertensive patients older than 35 years, with blood pressure higher than 140/90 mm Hg, who were willing to self-monitor their blood pressure. Patients were randomly assigned (1:1:1) to self-monitoring blood pressure (self-montoring group), to self-monitoring blood pressure with telemonitoring (telemonitoring group), or to usual care (clinic blood pressure; usual care group). Randomisation was by a secure web-based system. Neither participants nor investigators were masked to group assignment. The primary outcome was clinic measured systolic blood pressure at 12 months from randomisation. Primary analysis was of available cases. The trial is registered with ISRCTN, number ISRCTN 83571366.Findings1182 participants were randomly assigned to the self-monitoring group (n=395), the telemonitoring group (n=393), or the usual care group (n=394), of whom 1003 (85%) were included in the primary analysis. After 12 months, systolic blood pressure was lower in both intervention groups compared with usual care (self-monitoring, 137·0 [SD 16·7] mm Hg and telemonitoring, 136·0 [16·1] mm Hg vs usual care, 140·4 [16·5]; adjusted mean differences vs usual care: self-monitoring alone, −3·5 mm Hg [95% CI −5·8 to −1·2]; telemonitoring, −4·7 mm Hg [–7·0 to −2·4]). No difference between the self-monitoring and telemonitoring groups was recorded (adjusted mean difference −1·2 mm Hg [95% CI −3·5 to 1·2]). Results were similar in sensitivity analyses including multiple imputation. Adverse events were similar between all three groups.InterpretationSelf-monitoring, with or without telemonitoring, when used by general practitioners to titrate antihypertensive medication in individuals with poorly controlled blood pressure, leads to significantly lower blood pressure than titration guided by clinic readings. With most general practitioners and many patients using self-monitoring, it could become the cornerstone of hypertension management in primary care.FundingNational Institute for Health Research via Programme Grant for Applied Health Research (RP-PG-1209-10051), Professorship to RJM (NIHR-RP-R2-12-015), Oxford Collaboration for Leadership in Applied Health Research and Care, and Omron Healthcare UK.

No abstract

Agility is bringing in responsibility and ownership in individuals, which will eventually bring outeffectiveness and efficiency in deliverables. Agile model is growing in the market at very good pace.Companies are drifting from traditional Software Development Life Cycle models to Agile Environment forthe purpose of attaining quality and for the sake of saving cost and time. Nimbleness nature of Agile ishelpful in frequent releases so as to satisfy the customer by providing frequent dual feedback. InTraditional models, life cycle is properly defined and also phases are elaborated by specifying needed inputand output parameters. On the other hand, in Agile environment, phases are specific to methodologies ofAgile - Extreme Programming etc. In this paper a common life cycle approach is proposed that isapplicable for different kinds of teams. The paper aims to describe a mapping function for mapping oftraditional methods to Agile method

No abstract

No abstract

Abstract-Regression testing is a process that executes subset of tests that have already been conducted to ensure that changes have not propagated unintended side effects. Test case prioritization aims at reordering the regression test suit based on certain criteria, so that the test cases with higher priority can be executed first rather than those with lower priority. In this paper, a new approach for test case prioritization has been proposed which is based on a module-coupling effect that considers the modulecoupling value for the purpose of prioritizing the modules in the software so that critical modules can be identified which in turn will find the prioritized set of test cases. In this way there will be high percentage of detecting critical errors that have been propagated to other modules due to any change in a module. The proposed approach has been evaluated with a case study of software consisting of ten modules.

Honeypots act as security resources that are used to catch malign activities, so they may be anatomized and watched. During the past few years, they are called as a safeguard of assets of an organization. They are used to acquire information on interrupters in a network. This paper gives an introduction to the honeypots, their classification, detailed study of commercial as well as open source honeypots tools and comparison between them. This paper may be helpful for readers to secure their resources from intruders by using the freely available honeypots tools.

No abstract