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A short and efficient synthesis of cyrmenin B(1), an antifungal metabolite of myxobacteria Cystobacter armeniaca and Archangium gephyra, is described. The crucial steps of the synthesis included the formation of the dehydroalanine moiety from the corresponding serine acetate and the formation of the beta-methoxyacrylate system via trimethylsilyldiazomethane methylation of the corresponding beta-hydroxy enamide.

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A short and efficient synthesis of the novel cytotoxic natural product berkeleyamide A, isolated from a deep‐water Penicillium rubrum, has been accomplished. L‐Leucinol was used as the only chiral starting material. A diastereoselective aldol condensation is the key step in the synthesis.

First Total Synthesis of Prasinic Acid and Its Anticancer Activity. -A ten-step synthesis of prasinic acid (I) starting from readily available and cheap materials is presented. Compound (I) shows moderate antitumor activity in different cancer cell lines. -(CHAKOR, N.; PATIL, G.; WRITER, D.; PERIYASAMY, G.; SHARMA, R.; ROYCHOWDHURY, A.; MISHRA*, P. D.; Bioorg. Med. Chem. Lett. 22 (2012) 21, 6608-6610, http://dx.

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