This literature review focuses on the recent advances in the asymmetric hydrosilylation of ketones and imines. New catalyst systems based on various transition metals, such as rhodium, titanium, zinc, copper and tin, combined with classical or new ligand structures, are presented. These systems lead to very effective and selective protocols for the reduction of prochiral ketones, imines and electrophilic double bonds.
[reaction: see text] Copper(II) fluoride-chiral diphosphine systems catalyze the hydrosilylation of several ketones with moderate to excellent enantioselectivities. An oxygen acceleration effect was observed and led to a practical protocol with low catalyst loading.
An angiogenic microfiber patch that releases angiogenic growth factors along aligned fibers and subsequently directs the spacing and orientation of mature and functional blood vessel formation is presented. The fiber patches are prepared by electrostatically binding electrosprayed vascular endothelial growth factor (VEGF)‐encapsulating poly(lactide‐co‐glycolide) (PLGA) microparticles with electrospun poly(lactide) (PLA) microfibers.
A new copper(II) fluoride–chiral diphosphines catalytic system was developed. This one is very efficient and selective for the hydrosilylation of several substituted or unsubstituted aromatic ketones in so far as moderate to excellent enantioselectivities were obtained. An oxygen acceleration effect was observed that led us to propose a practical protocol with a low amount of catalyst.
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