Catalytic SbF5 and the use of EtOH as an additive efficiently converted a mixture of phenylalkynes and aldehydes to indanone compounds in one pot, and the reaction stereoselectively afforded the corresponding 2,3-disubstituted indanones as a single trans-isomer.

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Indan derivatives Q 1050Novel One-Pot Approach to Synthesis of Indanones Through Sb(V)-Catalyzed Reaction of Phenylalkynes with Aldehydes. -The 2,3-disubstituted indanones are obtained as single trans-isomer and the use of EtOH as additive is found to be essential. Lowering the reaction temperature allows the isolation of intermediate (V). -(SAITO*, A.; UMAKOSHI, M.; YAGYU, N.; HANZAWA, Y.; Org. Lett. 10 (2008) 9, 1783-1785; Lab. Org. React. Chem., Showa Pharm. Univ., Machida, Tokyo 194, Japan; Eng.) -Bartels 36-094