Childhood obesity and early rapid growth increase the risk for type 2 diabetes. Such early overnutrition can be modeled in mice by reducing litter size. We investigated the effects of early overnutrition and increased dietary fat intake on β cell function in Swiss Webster mice. On a moderate-fat diet, early overnutrition accelerated weight gain and induced hyperinsulinemia in pups. Early overnutrition males exhibited higher β cell mass but reduced islet insulin content and
Pdx1
expression. Males had a high diabetes incidence that was increased by early overnutrition, characterized by a progressive increase in insulin secretion as well as β cell death, indicated by histological analysis and increased circulating miR-375 levels. Females maintained normoglycemia throughout life. High-fat diet (HFD) increased diabetes incidence in males, whereas low-fat diet was completely protective. This protective effect was abolished in early overnutrition males transiently exposed to HFD in early life. Although Swiss Webster mice are not known to be diabetes-prone, the high diabetes incidence suggests an underlying genetic susceptibility that can be induced by overnutrition and increased dietary fat intake in early life. Thus, the nutritional environment in early life may impact long-term β cell function and increase diabetes risk, particularly in genetically susceptible individuals.
Aim Surgical site infections are disproportionately common after colorectal surgery and may be largely preventable. The objective of this retrospective cohort study was to determine the effect of oral antibiotics and mechanical bowel preparation on surgical site infections. What does this paper add to the literature? This is a quality improvement project monitoring our elective colorectal resections for surgical site infections (SSIs) before and after changes in preoperative bowel preparation. Our manuscript affirms that oral antibiotics and laparoscopic surgery significantly reduce SSIs for both colonic and rectal resections but SSIs for rectal resections still remain high.
P a g e 1 | U O J M e P u b | J a n u a r y 2 0 1 7Les professeurs de médecine reconnaissent que la responsabilité sociale est un pilier de l'éducation médicale canadienne; néan-moins, c'est un concept difficile à enseigner didactiquement. De plus en plus de preuves appuient l'intégration de la responsabilité sociale au curriculum médical à travers l'engagement communautaire. Heureusement, la Faculté de Médecine de l'Université de la Colombie-Britannique permet aux étudiants de participer à l'apprentissage par engagement communautaire en tant que composante du curriculum; nous, cinq étudiants en médecine, avons pu profiter de cette opportunité. Ce commentaire va promouvoir l'importance d'enseigner la responsabilité sociale dans les écoles de médecine par l'intermédiaire de l'apprentissage par engagement communautaire, basé sur la littérature disponible et notre expérience personnelle avec le quartier de Downtown Eastside de Vancouver (DTES).C o m m e n t a r y
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