Many studies have been conducted to establish the connection between exercise and telomere length, but still have varying results. Telomeres are reiterative DNA sequences (5'-TTAGGGn-3') which function to protect genomic DNA from enzymatic degradation. Telomere length can be used as a biomarker of aging because its repetitive structures are known to be highly relevant in the cellular aging process and the shortening of telomeres that occurs with increasing age is considered as an important contributor to aging in organisms. Several factors that affect telomere length are oxidative stress, chronic inflammation, BMI, lifestyle such as smoking, alcohol intake, stress, increased insulin resistance, and exercise. This study aims to determine the correlation of exercise at different intensities on telomere length. The method used in this study is internet search for journals and articles through several websites. The eligible criteria include studies in English language published between 2012 and 2022. The studies that report the correlation of different intensities exercise on telomere length were selected for the systematic literature review. As a result, the people who perform moderate to vigorous physical activity more in their leisure time, have longer leukocyte telomere length (LTL) and long-term resistance training may exert a protective effect on muscle telomere length in the elderly. Several studies have reported a correlation between prevention of leukocyte telomere length shortening and exercise at a certain intensity successfully.
Background. Excessive exercise increases oxidative stress, which affects cell damage, including Leydig cells. Damage to Leydig cells leads to a drop in testosterone levels. Vitamin E is known to protect spermatogenesis by inhibiting Leydig cell apoptosis and lipid peroxidation. This study investigates vitamin E efficacy in increasing Leydig cells count and testosterone levels in male Wistar rats exposed to excessive physical exercise. Methods. Thirty-six male Wistar rats were divided into the control and treatment groups in this posttest-only control group experimental study. The control group was a group that received excessive exercise and 1 ml/day of distilled water once daily. The treatment group was a group that received excessive exercise and vitamin E (20 mg/day) dissolved in distilled water up to 1 ml once daily. Excessive exercise in this study was swimming ≥ 60 minutes a day in an 80 cm x 50 cm pool with 60 cm deep. After 40 days; Leydig cells number and testosterone levels were examined and compared between groups. Results. Leydig cells' mean value in the treatment group was 2.6 times higher than the control (10.23±0.73 vs. 3.83±0.67; p<0.001). For testosterone levels, the mean value was 2.3 times higher in the treatment group compared to control (11.42±0.27 ng/mL vs. 4.94±0.21 ng/mL; p<0.001). Conclusions. Oral administration of vitamin E (20 mg/day) for 40 days increased Leydig cell number and testosterone levels in Wistar rats with excessive physical exercise compared to controls. Vitamin E might be considered a treatment for male Keywords: antioxidant; exercise; testosterone; vitamin E
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.