The exploitation of gas therapy platforms
holds great promise as
a “green” approach for selective cancer therapy, however,
it is often associated with some challenges, such as uncontrolled
or insufficient gas generation and unclear therapeutic mechanisms.
In this work, a gas therapy approach based on near-infrared (NIR)
light-triggered sulfur dioxide (SO2) generation was developed,
and the therapeutic mechanism as well as in vivo antitumor
therapeutic efficacy was demonstrated. A SO2 prodrug-loaded
rattle-structured upconversion@silica nanoparticles (RUCSNs) was constructed
to enable high loading capacity without obvious leakage and to convert
NIR light into ultraviolet light so as to activate the prodrug for
SO2 generation. In addition, SO2 prodrug-loaded
RUCSNs showed high cell uptake, good biocompatibility, intracellular
tracking ability, and high NIR light-triggered cytotoxicity. Furthermore,
the cytotoxic SO2 was found to induce cell apoptosis accompanied
by the increase of intracellular reactive oxygen species levels and
the damage of nuclear DNA. Moreover, efficient inhibition of tumor
growth was achieved, associated with significantly prolonged survival
of mice. Such NIR light-triggered SO2 therapy may provide
an effective strategy to stimulate further development of synergistic
cancer therapy platforms.
A novel squaraine-based chemosensor SQ-1 has been synthesized, and its sensing behavior toward various metal ions was investigated by UV-vis and fluorescence spectroscopies. In AcOH-H(2)O (40:60, v/v) solution, Hg(2+) ions coordinate with SQ-1 causing a deaggregation which induces a visual color and absorption spectral changes as well as strong fluorescence. In contrast, the addition of other metals (e.g., Pb(2+), Cd(2+), Cu(2+), Zn(2+), Al(3+), Ni(2+), Co(2+), Fe(3+), Ca(2+), K(+), Mg(2+), Na(+), and Ag(+)) does not induce these changes at all. Thus SQ-1 is a specific Hg(2+) sensing agent due to the inducing deaggregation of the dye molecule by Hg(2+).
[Structure: see text]. Ferrocenylketene (1) is calculated to be destabilized by 1.6 kcal/mol relative to phenylketene (10) by B3LYP isodesmic comparison to the corresponding alkenes. Ketene 1 generated by Wolff rearrangement in CH3CN is identified by the IR band at 2119 cm(-1) and has a rate constant for reaction with n-BuNH2 less than that for 10 by a factor of 5. 1,2-Bisferrocenyl-1,2-bisketene 18 and 1-ferrocenyl-2-trimethylsilyl-1,2-bisketene 21 were prepared by photochemical ring opening of the corresponding cyclobutenediones, and 18 undergoes rapid ring closure 67 times faster than the corresponding 1,2-diphenyl-1,2-bisketene, while bisketene 21 is longer lived than 18 by a factor of 3.2 x 10(4).
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