Foot and mouth disease and lumpy skin disease of cattle is a common disease on commercial cattle farms which associated with changes in behavior, blood parameters, pain related behaviors and pain scale measurements, but little is known about this effect. The objectives of the present study were to test 2 hypotheses. First, investigate these changes; second, explained the effect of different treatment strategies (analgesic with Flunixin meglumine) or non-analgesic on lameness and pain scale. 125 bull cows were enrolled in the study based on visual observation of abnormal behavior the present study was done in Assiut governorate in Egypt was divided in three groups, which 25 clinically healthy bull (control group), FMD clinically infected group (25 analgesic + 25 non-analgesic and LSD (25 analgesic + 25 non analgesic). Obtained data illustrated that; there are significant increase physiological parameters (rectal temperature, heart rate and respiratory rate), lying behavior and total pain scale, while, there are significant decrease in feeding, drinking, rumination and standing behaviors, activity of exploration and activity of body care which may be corrected by Flunixin using. Conclusion: Flunixin injection may help in decreasing the negative pain behaviors and physiological changes caused by LSD or FMD