Evolitrine (4,7-dimethoxyfuro[2,3-b]quinoline, 6a) was isolated from the dichloromethane extract of Evodia lunu-ankeda twigs. For the total synthesis the key chloro intermediate 3a was prepared in a novel way. The alkoxy, amino, dihydro derivatives of 6a were prepared. Evolitrine and some of its derivatives show anti-inflammatory activity.
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