Hidrocystomas are rare cystic lesions that form benign tumors of the sweat glands. In this report we present two classical cases of apocrine and eccrine hidrocystomas and review the epidemiological, histological and clinical features. The effectiveness of experimental treatment methods and present information about associated syndromes and differential diagnosis have also been discussed. KEY WORDS: Hidrocystomas, apocrine and eccrine hidrocystomas.
Cutis verticis gyrata (CVG) is a skin deformity characterised by excessive growth of skin of the scalp, resulting in furrows and folds which are similar to gyri of the brain cortex. A 25 year old male presented to the Dermatology department, Kempegowda institute of medical sciences with increased skin folds over scalp, forehead and face, increased oiliness of face, increased sweating, swelling of hands and feet and pain in limbs since 4 years. Routine blood investigation, thyroid function test and chest x-ray were normal Skull x-ray, x-ray of hands and feet showed cortical thickening of bones. CONCLUSION: We are presenting this case of CVG secondary to pachydermoperiostosis which is a rare case.
BACKGROUND AND OBJECTIVES: Macular amyloidosis (MA) represents a common variant of primary localized cutaneous amyloidosis with a characteristic female preponderance. Hyperpigmentation associated with MA poses a significant aesthetic problem for patients and there are no effective treatment modalities proven for the same. The present study was done to know the safety and efficacy of TCA (trichloroacetic acid) peel in the treatment of MA. MATERIALS & METHODS: A total of 25 patients with clinical diagnosis of macular amyloidosis were included in the study. TCA peel was done at an interval of 6 weeks between sessions. First session was done with 10% TCA and further sessions with 20 % TCA. Clinical response to treatment after each session was graded according to quarentile grading and any adverse effects were noted. RESULTS: A total of 25 patient. were included of which 22 were females and 3 males. Clinical improvement was more than 51% in 50% of patients after 3 sessions. Mean improvement scores increased proportionately with each session. Side effects included burning sensation during the procedure, peeling for almost 2 weeks and hyperpigmentation/ hypopigmentation. INTERPRETATION AND CONCLUSION: TCA peel is an effective and also cost effective treatment for the hyperpigmentation of macular amyloidosis. Disadvantages being long peeling time and possibility of hyper and hypopigmentation.
Werner's syndrome is a premature aging syndrome with autosomal recessive mode of inheritance. It is a rare case, hence early identification of disease and genetic counseling is important. AIM: To describe the clinical features of Werner's Disease in two siblings. CLINICAL PRESENTATION: A 34 year old female came with recurrent ulcers on lower limb, she was operated for bilateral cataract, hypopigmentation in B/L extensor surface of arm and waist, absence of axillary and pubic hair, loss of subcutaneous fat and the patient appeared old. Her younger sister, 33year old female came with similar complaints but less severe and had diabetes mellitus. H/O consanguineous marriage in parents. RESULT: Skin biopsy: Epidermis was thinned out, appendages are sparse and dermis showed thick hyalinised collagen. CONCLUSION: With Clinical features of premature aging, h/o consanguineous marriage, positive family history a diagnosis of Werner's disease was made. INTRODUCTION: Werner's syndrome is a progeroid syndrome. It is an autosomal recessive disorder characterized by an accelerated aging process after puberty. It is considered as an genomic instability syndrome. Mutation are present in DNA helicase gene. Cutaneous changes like atrophy, loss of subcutaneous fat, wrinkling, canities, loss of hair, defective pigmentation, sclerosis and ulceration. Diabetes Mellitus, posterior subcapsular cataract, atheroma and malignancies develop at an early age. 2 This article describes the clinical features of Werner's syndrome in two siblings. CASE REPORT: A 34 year old married nulliparous female came with recurrent ulcers on lower limb, the recurrent ulcers were seen on bony prominences like medial malleolus, she was operated for cataract of both the eyes 10 years back, depigmentation was present on in B/L elbows and extensor surface of arm, around the waist area, she had sparse grey hair on the scalp, absence of axillary and pubic hair, the face appeared aged, with beaked nose, loss of subcutaneous fat and the patient appeared old. Patient had poliosis of eyelashes her legs and hands were very slender and spindle shaped with loss of subcutaneous fat, the skin was taut stretched tightly over the bone with sclerodermatous skin changes. Obstetric History: Gravida-0, Para-0, Living-0.Menstrual history: attained menopause 2 years back, early attainment of menopause. Short stature 140 cm, patients weight was 25kgs .Her younger sister, 33year old female came with similar complaints, sparse hair, mottled pigmentation, dry atrophic skin, loss of subcutaneous fat, prematurely aged appearance, bird like facies, cataract of both eyes for which she was operated, H/O diabetes mellitus since 10 years on treatment, all her complaints were less severe compared to her elder sister. H/O consanguineous marriage in parents. Out of the five siblings, 1 male and 4 female, two of them were affected, rests of the siblings were normal. Complete haemogram: both the sisters were anaemic, ANA was normal in both, X-ray of the limbs was normal in both. Skin Biopsy From you...
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