The locomotor hyperactivity induced by 3,4-methylene dioxymethamphetamine (MDMA) and related drugs in rats appears to be due to the drug-induced release of presynaptic serotonin (5-HT). Thus, these drugs increase locomotor activity by acting as indirect 5-HT agonists.The subtype of 5-HT receptor upon which this released First, studies using the Behavioral Pattern Monitor
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