These data demonstrate that radiographic contrast agents impede fibrinolysis. This previously undescribed interaction was demonstrated using an in vitro test system, but these findings may have clinical relevance when thrombolytic drugs are used at the time of angiography.

No abstract

Rapid coagulation and fibrinolysis assays suitable for use with an imprecisely measured sample volume (either whole blood or plasma) have been developed, utilizing a technology based on paramagnetic iron oxide particles (PIOP) that move in response to an oscillating magnetic field. PIOP are combined with appropriate test reagents for clotting and thrombolysis assays and formulated as dry reagents within a capillary test chamber. The minima and maxima of the PIOP oscillations define a two-sided waveform that provides kinetic information on fibrin polymerization and lysis. Subject to the chemistry of the dry reagent formulation, the resulting waveform can be used to define clotting time, lysis onset time, or fibrinogen variables. Applications to one-stage prothrombin time and one-stage activated partial thromboplastin time tests have yielded assays with consistently good correlations with other test methods. Applications to fibrinolysis studies have yielded global assays of thrombolytic activity, in that the assay results reflect the interactions of multiple factors associated with the effectiveness of thrombolytic therapy. Depending on the components utilized in a particular reagent formulation, one can derive information about the activity of such factors as fibrinogen, plasminogen, and related inhibitors, as well as the lytic agent being administered. Use of these assays in a clinical setting should provide a rapid, convenient alternative to conventional testing of coagulation variables and a reliable method for monitoring thrombolytic therapy.

Electronic absorption spectra of a monodentate W(CO)5L intermediate have been recorded during the photoinitiated reaction of W(CO)5L with L = 1,4-di-t-butyI-l,4-diazabutadiene and 2,2'-bipyridine; the W(CO)5L species subsequently extrudes CO in a first order kinetic process to form W(CO)4L.

Elektronenabsorptionsspektren zeigen bei der Photolyse der Metallcarbonyle in Benzol in Gegenwart von 1,4‐Di‐tert.‐butyl‐1,4‐diazabutadien die rasche Bildung eines primären Reaktionsintermediäres, das als eine Solvens‐verunreinigte Spezies erkannt wird.