Compensatory upregulation in endogenous antioxidants has been shown to accompany certain genetic and dietary deficiencies that promote oxidative stress, including that related to Alzheimer's disease. We compared antioxidant levels in brain tissue of normal and transgenic mice lacking apolipoprotein E following dietary deprivation of vitamin E or folate. As described previously, ApoE-deficient mice displayed increased levels of the endogenous antioxidant glutathione as compared to normal mice, and increased these levels further following folate deprivation. By contrast, glutathione was depleted following vitamin E deprivation in brain tissue of normal and ApoE-deficient mice. TBAR analyses confirmed increased oxidative damage following vitamin E deprivation. However, combined deprivation of folate and vitamin E resulted in levels of glutathione intermediate between those observed following deprivation of either agent, indicating that the lack of compensatory increase in glutathione following vitamin E deprivation was not due to overt neurotoxicity. Similar results were observed for total antioxidant levels in brain tissue. The differential response to vitamin E and folate deprivation is consistent with the possibility that specific differences in oxidative damage may result from deficiencies in either of these agents. The lack of a compensatory response to vitamin E deprivation highlights the importance of dietary vitamin E in prevention of chronic neurodegeneration.
A partir de la presente investigación se analiza la intención emprendedora de las madres de familia, quienes son beneficiarias del Movimiento Fe y Alegría, establecido en la zona norte de Bucaramanga, Santander. El análisis se realiza a partir de una evaluación a un total de 20 grupos poblaciones, teniendo en cuenta factores sociodemográficos. Este se basa en la interpretación acerca de cómo las características personales y los factores del entorno, logran influenciar la intención emprendedora, de quienes han sido elegidas como población objeto de estudio, para esta investigación. La metodología utilizada se establece a partir de un análisis cuantitativo de enfoque descriptivo, así como de un diseño de estudio no experimental y transversal. Los hallazgos más representativos permiten evidenciar una predisposición positiva, para la creación de unidades empresariales, la cual está mediada por características personales inherentes a factores como los riesgos, la capacidad de escucha, el locus de control interno, la resolución de problemas, la disciplina y la pasión, así como a factores del entorno, referentes al apoyo familiar. Al mismo tiempo, se resalta aquí el interés de las madres por recibir capacitación, principalmente en temas de administración, emprendimiento y belleza.
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