distinct growth delays: an initial tumor growth delay significant over radiation alone at day 22, and a second late response at day 43; but did not translate to a survival advantage over RT. At day 14, UAMC-1110 treatment resulted in fewer intratumoral myeloid cells. At day 23, RT increased CD11b tumor infiltrate, MDSCs, and CD3 infiltrate. Tumors from combination treated mice had increased Gr1 HI cells and CD4 T cells, including Tregs. Macrophages increased with UAMC-1110, RT, and combination therapy in an additive manner. While CD8 to CD11b ratio increased with UAMC-1110 treatment, only 3 CD8 T cells were present per 100 myeloid cells. Tumor immune infiltrate was equivalent at day 43. Radiation increased collagen deposition, which was not altered by addition of UAMC-1110. Conclusion: We tested a novel specific FAP inhibitor with radiation in a murine PDAC model. We found FAP inhibition altered tumor immune infiltrate and caused two temporally distinct decreases in tumor growth when combined with RT. Interrogation of tumor immune infiltrate demonstrates alterations in innate and adaptive immune populations.
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