BACKGROUND
Malignant adenomyoepithelioma (AME) of the breast is a rare tumor in which malignancy can arise from either epithelial or myoepithelial components, or from both cell types. The incidence and prognosis of malignant AME of the breast are difficult to assess due to its rarity. Therefore, the optimal treatment for this disease is still controversial.
CASE SUMMARY
We present two middle-aged women (48 and 56 years old) with malignant AME of the breast. Core needle biopsy was performed before surgery. However, breast adenoma and malignant tumors were observed. The preoperative diagnosis of malignant AME of the breast is still challenging for pathologists and clinicians. Both patients underwent mastectomy and sentinel lymph node biopsy, both of which were negative, followed by adjuvant chemotherapy.
CONCLUSION
The follow-up duration of the two patients was two years and four months, respectively. No signs of relapse or metastasis have been observed thus far.
Aggressive fibromatosis, also referred to as desmoid-type fibromatosis or desmoid tumor, is an uncommon locally invasive tumor with a high local recurrence rate. It rarely occurs in the breast and the etiology of aggressive breast fibromatosis is still unknown but may be related to previous mammary trauma or surgery. Preoperative diagnosis of aggressive breast fibromatosis is still a challenge for clinicians. The optimal treatment for the disease is still controversial, but wide surgical excision with negative margins is considered the standard option. We report a 28-year-old woman of aggressive breast fibromatosis accompanied with accessory breast mastitis in her ipsilateral axilla. The lesions imitated breast carcinoma with axillary lymph node metastasis due to their similar clinical and imaging manifestations. Her mammary mass finally underwent wide surgical excision, and negative margins were confirmed during the surgery. To our knowledge, this is an extremely rare case accompanied with axillary accessory breast mastitis and will contribute to the management of aggressive breast fibromatosis.
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