A novel Fe-catalyzed cyclization of ketoxime carboxylates and methyl carbon on N,N-dimethylaniline for the synthesis of 2,3,5,6-tetrasubstituted symmetrical pyridines was developed.

Citation denotes calendar and volume year of first online publication.

An asymmetric organocatalyzed three-component Povarov reaction to construct azaspirocycles has been developed. A chiral phosphoric acid OCF-CPA bearing o-CF 3 -aryl on the H 8 −BINOL-framework is highly efficient in the reaction. The reaction was carried out under mind conditions for synthesis of a range of azaspirocycles in high yields and high to excellent enantioselectivities, thus expending the substrate scope of the traditional Povarov reaction.