The objectives of study were to assess the knowledge regarding pre-eclampsia and self-care measures among pregnant woman. Find out an association between knowledge regarding pre-eclampsia and self-care measures and selected variables, develop an informational booklet on pre-eclampsia and self-care measures. Methods The design selected for the study is descriptive design. The study was conducted on 108 antenatal mothers below 20 weeks of gestational age and who are attending antenatal outpatient department of Dr KLES Prabhakar Kore's Hospital, Belgaum. Non- probability purposive sampling technique was used. The tool included background proforma, knowledge and self-care measures questionnaire on preeclampsia. The data was analyzed in terms of both descriptive and inferential analysis. Results Data analysis of level of knowledge revealed majority of mothers 80(74.07%) had average knowledge, 14(12.96%) had good and poor knowledge; and with regards to self-care measures (60.18%) had average knowledge, 41(37.96%) had good knowledge and 2(1.85%) had poor knowledge, association between the knowledge of mothers and selected variables revealed that the variables age, educational status, occupational status, income, religion, parity and area of residence shows an association with knowledge scores at 0.05 level of significance. Association between the self-care measures scores of mothers and selected variables revealed that the variables age, educational status, occupational status, income, religion and parity shows an association with knowledge scores at 0.05 level of significance. The variable type of family and area of residence in relation with knowledge scores of mothers are independent of each other. Conclusion The world has come a long way from the times when a woman surviving childbirth was considered to be blessed with a 'second life’ to the present. Application of appropriate prenatal care and management has largely eliminated maternal mortality frequently at the cost of preterm delivery. Based on the findings of the study, it is concluded that most of the subjects had average knowledge regarding preeclampsia and its self-care measures.