The present study comprises determination of stability constant and the thermodynamics of interaction of transition metal ion Mn(II) with antibiotics Ciprofloxacin. The formation of 1:1 and 1:2 metal ligand complexes are found to be formed in 50 %(v/v) methanol-water system. The stability constant values for metal-ligand system compared at three temperetures, it is found that value of stability constant decreases with increasing temperature. This is in agreement with the conclusion of Pitzer 1 .
nm. The different experimental parameters affecting the development and stability of the colour were carefully studied and optimized. Here the selected drug is β-blocker having amino group so the chealation with cu (ll) ion is easily and stable.
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