Intravenous tranexamic acid, administered before skin incision, significantly reduced the requirement for additional uterotonics among women at increased risk for postpartum hemorrhage. Clinical Trials Registry India: CTRI/2015/05/005752.
Cesarean sections are being performed more frequently nowadays. In most cases, it is also the first visit to the operating room for the woman, with its associated anxieties and apprehensions. The young age and female gender, in addition, make them more vulnerable to pain. Also, new mothers cannot afford the luxury of prolonged convalescence. They are expected to actively take care of the new born. Because pregnancy is a risk factor for thromboembolic phenomena, early mobilization after delivery is recommended. Good pain relief is required for this. All of these have contributed to the search for newer and more effective methods of pain control after cesarean birth. The conventional methods of analgesia have centered on the use of opioids given via diverse routes like systemic and neuraxial. Patient-controlled analgesia with elastomeric pumps has made this more acceptable and satisfying to the patients. However, opioids have some unwanted effects like pruritus and respiratory depression. In addition, secretion into breast milk is a unique concern in this population. Drugs like Non-Steroidal Anti Inflammatory Drugs (NSAID) and paracetamol can only supplement other modes of analgesia and are not sufficient on their own. Neuraxial methods, though effective and safe, need to be performed by an experienced person and require a higher level of monitoring. Regional field blocks like Transversus Abdominis Plane (TAP) block and iliohypogastricilioinguinal nerve blocks are gaining in popularity, especially after the advent of ultrasound in anesthesia. Wound infiltration catheters are also in vogue.
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