Background: The quality of working life (QWL) is increasingly considered in organizations interested in job satisfaction (JS) and enhancing organizational effectiveness. Objective: The current study aimed at investigating the QWL and JS in the employees of health centers in Ahvaz, Iran. Methods: In the current descriptive-analytical study, 143 technical staff of health centers in East of Ahvaz were selected by the multistage random sampling method in 2015. Data were collected using 2 questionnaires. Data were analyzed through descriptive statistics, the Pearson correlation coefficient and multiple linear regression with SPSS version 21. Results: Overall, the Walton QWL questionnaire scored 72.95 and the JS survey scored 126.08 were in the moderate level in the current study. There was a significant relationship between QWL and JS (P = 0.00).Moreover, there was a significant relationship between JS and all components of QWL (P = 0.00). The highest and lowest correlation was related to social cohesion (0.539) and safe environment (0.212), respectively. Results of the regression analysis showed that the QWL explained 39.6% of the variance affecting the JS (R 2 = 0.396, P = 0.00). Among the dimensions of QWL, growth and security (β = 0.190, P = 0.03), rule of law (β = 0.277, P = 0.00) and
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