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BackgroundLipoprotein lipase (LPL) is a rate limiting enzyme responsible for the hydrolysis of triacylglycerol‐rich lipoproteins releasing monoglycerides and free fatty acids, which are taken up by skeletal muscles, adipose tissue.AimTo investigate the effect of genetic polymorphisms of LPL S447X and Hind III on blood pressure and its related phenotype.MethodsS447X variant genotype and Hind III (+) variant of LPL were determined by polymerase reaction restriction fragment length polymorphism (PCR‐RFLP) assay in 50 hypertensive patients and 50 normotensive as a control group. Anthropometric measurements and serum lipoproteins were also determined in both groups. Analysis of data was done by using SPSS program.ResultsThe frequency of (SS) and (H+/H+) genotype were 78% and 62% respectively in the hypertensive group compared to 66% and 38% in normotensive group. Carrier of either (SS) or (H+/H+) genotype were at higher risk of developing hypertension (OR=1.8, 95% CI=0.8–4.4) and (OR=2.4, 95% CI =1.1–5.5) respectively when compared with carrier of other genotypes. The risk for hypertension was increased when the individuals were carrier of (SS) and (H+/H+) haplotype (OR = 6 and 95% CI =2.5–14.2). Furthermore carrier of either (SS) or (H+/H+) genotype were at higher risk of developing atherogenic phenotype manifested by central obesity and/or abdominal obesity and dyslipdemia.ConclusionIt was found that carriers of (SS) genotype and/or (H+H+) genotype were at high risk of developing hypertension and its related atherogenic phenotypes.Source of research support: Dubai Medical College for Girls