Schizophrenia (SZ) is a complex disabling disorder that leads to the mental disability and afflicts 1% of the world's total population and placed in top ten medical disorders. In current work, bioinformatics analyses were carried out on Trace amine (TA)‐associated receptor 6 (TAAR6) to recognize the potential drugs and compounds against SZ. Comparative modeling and threading‐based approaches were utilized for the structure prediction of TAAR6. Fifty‐nine predicted structures were evaluated by various model assessment techniques and final model having only eight amino acids in the outlier region and 98.5% overall quality factor was chosen for further pharmacoinformatics and molecular docking analyses. From an extensive literature review, 11 Food and Drug Administration (FDA) approved drugs were analyzed by computational techniques and Aripiprazole was found as the most effective drug against SZ by targeting TAAR6. Here, we report five novel molecules which exhibited the highest binding affinity, effective drug properties, and interestingly, observed better results than the approved selected drugs against SZ by targeting TAAR6. The docking analyses revealed that Arg‐92, Trp‐98, Gln‐191, Thr‐192, Ala‐290, Cys‐291, Tyr‐293, and Glu‐294 residues were observed as critical interacting residues in receptor‐ligand interactions. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties, Lipinski rule of five, highest binding affinity coupled with virtual screening (VS), and pharmacophore modeling approach illustrated that aripiprazole (−8.6 kcal/mol) and TAAR6_0094 (−9.3 kcal/mol) are potential inhibitors for targeting TAAR6. It is suggested that schizophrenic patients have to use Aripiprazole for the medication of SZ by targeting TAAR6 and develop effective therapies by utilizing scrutinized novel compound.

Over a past few years, a very limited number of studies researched whether the chikungunya virus affects the oral cavity in addition to pronounced symptoms in extremities but on literature review different studies were found to have different conclusions. Thus an Observational Study was conducted evaluating the impact of Chikungunya Virus Infection on Oral Cavity and Temporomandibular Joint. This was a cross sectional study having a self-designed questionnaire, descriptive and associative tests were run for Data analysis using SPSS. Out of 527 tested, 204 patients were found seropositive and 135 were selected for data analysis on their consent (N 135). Pain and burning sensation of mouth (71.1%), discomfort in mouth opening (65.9%), Bleeding gums (53.3%), and taste aversion (50.3%) were the most common complaints followed by Inability to chew food (48.1%), Discomfort in swallowing (35.5%), Halitosis (34.8%) and tenderness over TMJ (30.4%). The study significantly recorded pain, discomfort and bleeding gums intraorally. Pain, tenderness and decreased efficiency of temporomandibular joint were also noted. Contribution/Originality: This study contributes in the existing literature of Chikungunya virus infection. Interval estimation statistical method is used. It is one of very few studies which have investigated impact of Chikungunya Virus Infection on Oral Cavity and Temporomandibular Joint and concluded it to be quite painful and uncomfortable to bear causing burning gums, limiting speech, decreased chewing ability, altering taste perception, TM-joint and muscles tenderness and difficulty in food swallowing. regions, but it has the potential to affect more than 1 billion people [3]. Since 2005, major breakouts of chikungunya virus have occurred in India, Indonesia, Maldives, Myanmar and Thailand have reported over 1.9

Objective: To determine the Rhinoplasty as a powerful tool to boost patient's self-confidence. Study Design: Prospective study. Settings: Islamabad cosmetic surgery and department of plastic surgery PIMS Islamabad Pakistan. Duration: From October 2019 March 2020. Methodology: All the patients underwent rhinoplasty having age 18 to 50 years and wither of gender were included. Rhinoplasty outcomes Evaluation (ROE) questioner containing (6 questions, was used to assess improvement of patient's self-confidence. All the data was recorded by study proforma. Data was analyzed by using SPSS version 20. Results: Total 51 patients were assessed; their mean age was 28.54+6.65 years. Male were 27(52.9%) and females were 24(47.1%). After 3 months postoperatively patients were assessed, according to (ROE) questioner. Almost all the patients were completely agree with the appearance their nose, they can completely breath and feeling very much and completely their friends and loved ones like their nose. All the patients were confident regarding their nasal appearance as it is the best that it can be and refused, when they were asked regarding that they want to alter appearance or function of their nose surgically. Conclusion: Rhinoplasty is the best tool to boost patient's self-confidence having nose common deformities. Almost all the participants were satisfied, good feeling and confident after surgery.