Introduction:Bone is an uncommon site of involvement in hydatid disease; with the prevalence of 0.5-2% among bone lesions. Case Presentation: In this study, we report the treatment of 5 cases of hydatid disease of tibia by curettage of the lesion; wash with Betadine lotion and hypertonic saline and filling the cavity with poly methyl metacrylate (PMMA) bone cement. After operation, we continued treatment with oral mebendazole for 6 months. Conclusions: With the average 89-months follow-up, no recurrence of the diseases was found in the patients. It seems that using of cement and oral anti-parasitic, after extensive resection of the lesion is a proper treatment of bone hydatid disease.
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