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Background: Systemic Erythematosus (SLE) is a chronic, complicated and challenging disease to diagnose and treat. The etiology of SLE is unknown, but certain risk factors have been identified that lead to immune system dysregulation with pathogenic autoantibody formation and immune complex deposition. Aim of Study: To assess blood concentration of CD5+ B cells in patients with SLE and to evaluate their relationship with SLE disease activity. Patients and Methods: The present study included forty SLE patients who were selected from outpatient clinic of Rheumatology and Rehabilitation of Ain Shams University Hospital and diagnosed according to new EULAR and ACR classification criteria. Based on SLEDAI, the patients were selected and divided into two groups. The first group included 20 patients with inactive disease and the second group included 20 patients with active disease. They were matched with ten healthy individuals as a control group, and all were subjected to full history, clinical examination, ESR, CRP, serum complements, anti-dsDNA, ANA, serum creatinine twenty-four hours urinary proteins as well as CD5+ B lymphocytes by flow cytometric analysis. Results: In the present study, the percentage of CD5+ B lymphocytes per total lymphocytes were significantly decreased in SLE patients compared to healthy individuals. Moreover, the percentage of CD5+ B lymphocytes per total B cells were significantly decreased in SLE patients compared to controls. We also have found a statistically highly significant decrease in the percentage of CD5+ B cells in active SLE patients compared to inactive patients. As regards the correlation studies, the results revealed a positive correlation between CD5+ B cells and each of platelets, C3 and C4. Moreover, the diagnostic performance of CD5+ B cells was evaluated and our results showed that CD5+ B cells can discriminate SLE patients from controls, and can predict the disease activity. Conclusion: The proportions of CD5+ B cells were significantly decreased in SLE patients than normal people, and

Objectives: To compare the efficacy between platelet-rich plasma (PRP) and corticosteroids (CS) in improving magnetic resonance imaging (MRI)-detected synovitis in correlation with clinical complaints among patients with lumbar facet joint (FJ) disease.Methods: This study was carried out at Eldemerdash Hospital, Cairo, Egypt between September 2019 and January 2021. A prospective, randomized, comparative, single blinded study included 30 patients with lumbar Original ArticleFJ disease, divided into 2 equal groups, received PRP and CS injections. Patients were comparatively assessed before and after the intervention according to number of tender lumbar FJs, maximum active lumbar extension range of motion, LBP visual analogue score, LBP functional disability questionnaires and MRI lumbar FJ detected synovitis and their grading.Results: Both groups showed a significant improvement in all mentioned parameters at follow-up after 3 months. However, PRP injections promoted better performance in terms of MRI synovitis grade in all lumbar FJ levels compared to CS injections. Conclusion:Both PRP and CS injections were effective in improving MRI-detected FJ synovitis while concurrently improving all examined parameters at follow-up after 3 months. However, PRP promoted better improvement in MRI-detected synovitis grade, suggesting that it may be a better treatment option for longer duration efficacy.