The motive behind present work was to formulate and evaluate gel containing microsponges of diclofenac diethylamine to provide prolonged release for proficient arthritis therapy. Quasi-emulsion solvent diffusion method was implied using Eudragit RS-100 and microsponges with varied drug-polymer ratios were prepared. For the sake of optimization, diverse factors affecting microparticles physical properties were too investigated. Microsponges were characterized by SEM, DSC, FT-IR, XRPD and particle size analysis, and evaluated for morphology, drug loading, in vitro drug release and ex vivo diffusion as well. There were no chemical interactions between drug and polymers used as revealed by compatibility studies outcomes. The drug polymer ratio reflected notable effect on drug content, encapsulation efficiency and particle size. SEM results revealed spherical microsponges with porous surface, and had 7.21 μm mean particle size. The microsponges were then incorporated in gel; which exhibited viscous modulus along with pseudoplastic behavior. In vitro drug release results depicted that microsponges with 1:2 drug-polymer ratio were more efficient to give extended drug release of 75.88% at the end of 8 h; while conventional formulation get exhausted incredibly earlier by releasing 81.11% drug at the end of 4 h only. Thus the formulated microsponge-based gel of diclofenac diethylamine would be a promising alternative to conventional therapy for safer and efficient treatment of arthritis and musculoskeletal disorders.
The rationale behind present work was to formulate a novel cream containing microsponges of miconazole nitrate to provide prolonged release. By means of quasi-emulsion solvent diffusion method using Eudragit RS-100 with different drug-polymer ratios microsponges were prepared. In the direction of optimizing microsponge formulation, diverse factors that affect microparticles physical properties were also investigated. Microsponges were characterized by SEM, DSC, FT-IR and particle size analysis, and also evaluated for morphology, drug loading and in vitro drug release. The drug polymer ratio reflected notable effect on drug content, encapsulation efficiency and particle size. It has been found that there was no chemical interaction between drug and polymers used as revealed by FT-IR and DSC spectra. SEM micrographs exposed that microsponges were spherical, with porous surface and have had 26.23 μm mean particle size. The microsponges were then incorporated in cream; which showed viscous modulus along with pseudoplastic behavior. In vitro drug release results depicted that microsponge with drug-polymer ratio of 1:2 was more efficient to give extended drug release of 78.28% at the end of 8 h; while conventional formulations get exhausted incredibly earlier by releasing 83.09% drug at the end of 4 h only. Thus the formulated cream containing microsponges of miconazole nitrate would be a promising alternative as compared to conventional therapy for secure and efficient treatment of acne and other topical infections.
Nanotechnology is an escalating field that has made its contribution to all spheres of human life. The green synthesis of nanoparticles has paved for better methodologies and approaches in the medicinal field. Nowadays silver, gold and other metallic nanoparticles are used as an efficient carrier for drug molecules for developing novel drug delivery systems. In course of synthesizing these nanoparticles various chemicals, solvents and reagents are used which harms our eco system directly or indirectly. Silver nanoparticles (Ag NPs) have been widely used as a novel therapeutic agent extending its use as antibacterial, antifungal, anti-viral and anti-inflammatory agent. Silver nanoparticles (Ag NPs) prepared by green synthesis have many advantages over conventional methods involving chemical agents associated with environmental toxicity. Green synthetic methods include polysaccharide method, irradiation method, biological method, polyoxometallates method and tollens method. Green synthesis of nanoparticles is found to be an emerging branch of nanotechnology. The use of environmentally benign materials like plant leaf extract for the synthesis of nanoparticles offers numerous benefits of eco-friendliness and compatibility for pharmaceutical and biomedical applications as they do not use toxic chemicals in the synthesis protocols. Rapid and green synthetic methods using various plant extracts have shown a great potential in silver nanoparticles (Ag NPs) synthesis. This review article describes the bio-inspired synthesis of nanoparticles that provides advancement over chemical and physical methods as it is cost effective, eco-friendly and more effective in a variety of applications.
This review article describes the synthesis, properties and some applications of star-shaped polymers. The arms constituted of homo- or co-polymers of different polymers are also reviewed. Methods of synthesis of various types of star-shaped polymers, including “arm first” and “core first” procedures, is given as an introduction along with some details. Then, the synthesis of star polymers (including miktoarm stars) with strictly defined as well as with varying number of arms and having cores formed from small and/or large molecules: branched, cross-linked, etc., is described. Interest in star-shaped and branched systems based on poly (ethylene oxide) (PEO) is mainly motivated by their potential applications in the biomedical and pharmaceutical areas. The properties and applications of PEO stars are also reported, such as drug carriers, surface modifiers, hydrogels, components of membranes, and also have some biomedical applications. Their potential applications as components of different types of complexes, hydrogels, networks, and ultrathin coatings are indicated.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.